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Antimicrobial Activity of Rubia cordifolia: Methods to Determine Antimicrobial Activity

Conclusion: Rubia cordifolia root extracts showed antimicrobial effects. Using pour plate technique in agar well diffusion method is more sensitive in showing antimicrobial effectiveness than using spreading technique.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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RIMA Abstract Metastasis remains the most common cause of death in cancer patients. Inhibition of metalloproteinases (MMPs) is an interesting approach to cancer therapy because of their role in the degradation of extracellular matrix (ECM), cell-cell, and cell-ECM interactions, modulating key events in cell migration and invasion. Herein, we show the cytotoxic and antimetastatic effects of the third fraction (FR3) from Bauhinia variegata candida (Bvc) stem on human cervical tumor cells (HeLa) and human peripheral blood mononuclear cells (PBMCs). FR3 inhibited MMP-2 and MMP-9 activity, indicated by zymogram. This ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Here, the authors report a rapid, simple, and eco-friendly process for synthesis of Bi2O3 nano-needles. Dioscorea alata tuber extract was used as both reducing and capping agent for the first time. These nanoparticles were characterised by X-ray diffraction, field emission scanning electron microscope, and Fourier transform infrared (FTIR) spectrometry, the nano-structured Bi2O3 needles have an average diameter of 158 nm with the lengths in the range of 1–3 μm. CLSI M27-A2 standard was followed for evaluation of anti-fungal activity. Bi2O3 nano-needles show remarkable activity against Candida albicans. It exhi...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Publication date: Available online 18 May 2018 Source:Journal de Mycologie Médicale Author(s): S. Dabiri, M. Shams-Ghahfarokhi, M. Razzaghi-Abyaneh Candida species are the commensal organisms of human and animal mucosa that cause a wide range of debilitating diseases in immunocompromised patients and other susceptible individuals. The present study aimed to investigate the ability of clinical isolates of various Candida species to produce proteinase and phospholipase, hydrophobicity and biofilm forming ability that assumed to have a vital role in Candida pathogenicity. Eighty-four Candida strains belonged to Candid...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
AbstractCandida endocarditis represents a life-threatening infection with high mortality rates despite adequate antifungal treatment. Step-down oral treatment with fluconazole or voriconazole represents a treatment option for clinically stable patients. Drug toxicity, however, is reported during azole therapy and can be challenging, especially among patients with multiple comorbidities. This is the first report that highlights the impact of isavuconazole on the corrected QT interval and liver toxicity in a cirrhotic patient withCandida endocarditis.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
In conclusion, we report that CgMed3AB functions as a wheel responsible for driving cellular acetyl-CoA metabolism, indirectly inducing the transcription of Cgcln3 and coordinating cell growth (Fig. 1). We propose that mediator subunits may represent a vital regulatory target modulating cell growth in C. glabrata. PMID: 29776932 [PubMed - as supplied by publisher]
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
In conclusion, the developed ZnO/Ag surfaces exhibit not only high antibacterial activity but also some antifungal activity. Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Conclusion This work provides new insights into C. albicans metabolism, cell wall and virulence.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Conclusions: While a significant exposure–response relationship was not found, PK–PD experiments support higher exposures of micafungin in infants with invasive candidiasis. More patients would clarify this relationship; however, low incidence deters the feasibility of these studies.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research
Authors: Guragai N, Rampal U, Vasudev R, Shah D, Patel H, Salamera J, Pullatt R, Shamoon F Abstract Pulmonary valve infections without the involvement of other valves account for only 1.5- 2% of all infective endocarditis cases. Isolated pulmonary valve endocarditis due to fungus is extremely rare. The case is presented of a 36-year-old male who was found to have isolated pulmonary valve endocarditis caused by a very rare organism, Candida parapsilosis, and that was solely managed with medical therapy. The patient was evaluated for three weeks of lowgrade fever, generalized rash and fatigue, and found to have C. pa...
Source: Journal of Heart Valve Disease - Category: Cardiology Tags: J Heart Valve Dis Source Type: research
Conclusions Radical resection and in-situ reconstruction with CPA avoids placing prosthetic material in an infected field and provides good early and mid-term outcomes. However, early postoperative imaging is necessary given the risk of pseudoaneurysm formation.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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