Antibacterial Tests Against Acne in vitro, the Physical Stability and Patch Test using Cream Containing Ethyl p-methoxycinnamate Extracted from Kaempferia galanga L., Rhizoma

Background and Objective: An activity of certain bacterias is one of the causes of acne. Rimpang kencur (Kaempferia galanga L. ) has an antibacterial agent from compound ethyl p-methoxycinnamate (EPMC). The purpose of this study is to find out the antibacterial activity using EPMC against P. acne, S. aureus and S. epidermidis with the physical stability of the cream and its safety use as an antiacne cream. Materials and Methods: The antibacterial activity and minimum inhibitory concentration of EPMC are 0.3, 0.6, 1.2 and 2.4% was done using disc diffusion method and broth dilution test. Data obtained from in vitro test of bacterial activity was analyzed using descriptive analysis and Complete Randomized Design (CRD) with 99% (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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In this study, we examined the effects of PPI on the production of inflammatory cytokines in HaCaT keratinocytes treated with heat-killedP. acnes. These treated HaCaT keratinocytes showed increased expression of Toll-like receptor 2 (TLR2) and production of inflammatory cytokines. PPI significantly suppressed the secretion of inflammatory cytokines, including interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)- α, and the expression of TLR2 inP. acnes-treated cells. Moreover, we studied the influence of PPI on the nuclear factor- κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathw...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Rosy cheeks can be the result of many benign causes, such as being hot. However, there are several causes that may require medical attention, including acne, rosacea, and lupus. We look at some of the causes of facial flushing and explain the steps that people can take to treat, manage, and prevent them.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dermatology Source Type: news
Updated Date: Aug 17, 2018 EST
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British Journal of Dermatology, EarlyView.
Source: British Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Updated Date: Aug 15, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Aug 15, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Updated Date: Aug 15, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
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Source: Journal of Cosmetic and Laser Therapy - Category: Laser Surgery Authors: Source Type: research
Nicastrin (NCSTN) mutations are associated with familial acne inversa (AI), and emerging evidences suggest that microRNAs (miRNAs) are involved in various skin diseases. However, whether NCSTN mutations affect miRNA levels and their subsequent signaling pathways in familial AI patients has not been studied. We aimed to elucidate the relationship between NCSTN mutations and familial AI pathogenesis by investigating differential miRNA expression and their related pathways. Combined with miRNA microarray data from familial AI patients, Ncstn keratinocyte-specific-knockout (Ncstn ΔKC) mice and bioinformatics predictions ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Ondrej Slaby, Andrew McDowell, Holger Br üggemann, Assaf Raz, Sibel Demir-Deviren, Tony Freemont, Peter Lambert, Manu N. Capoor
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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