Abstract B14: Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.

In conclusion, we uncovered a feedback loop between atypical E2Fs and APC/CCdh1, which ensures balanced expression of cell cycle genes and normal cell cycle progression.Citation Format: Michiel Boekhout, Ruixue Yuan, Annelotte P. Wondergem, Hendrika A. Segeren, Elsbeth A. van Liere, Nesibu Awol, Imke Jansen, Rob MF Wolthuis, Alain de Bruin, Bart Westendorp. Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr B14.

Source: Molecular Cancer Research - November 9, 2016 Category: Cancer & Oncology Authors: Boekhout, M., Yuan, R., Wondergem, A. P., Segeren, H. A., Liere, E. A. v., Awol, N., Jansen, I., Wolthuis, R. M., Bruin, A. d., Westendorp, B. Tags: E2F Family Functions: Alterations and Consequences: Poster Presentations - Proffered Abstracts Source Type: research