Abstract PR13: Germ-line mutations in CDC20 result in familial cancers via deregulation of the cell cycle

Conclusions: Our preliminary data suggest that L151R and N331K may drive cancer through the insensitivity of Cdc20 to the SAC. To our knowledge this is the first description of CDC20 as a cancer predisposition gene. The rapid division of cancer cells demands that they maintain high APC activity and this may represent an Achilles heel that can be exploited therapeutically.This abstract is also being presented as Poster B25.Citation Format: Ester Castellsague, Jian Carrot-Zhang, Isabelle Gamache, Barbara Rivera, Mohamed Moustafa, David Barford, Jacek Majewski, Jose Teodoro, William David Foulkes. Germ-line mutations in CDC20 result in familial cancers via deregulation of the cell cycle. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr PR13.

Source: Molecular Cancer Research - November 9, 2016 Category: Cancer & Oncology Authors: Castellsague, E., Carrot-Zhang, J., Gamache, I., Rivera, B., Moustafa, M., Barford, D., Majewski, J., Teodoro, J., Foulkes, W. D. Tags: Other Topics: Oral Presentations - Proffered Abstracts Source Type: research