Abstract IA10: The senescence response - yin and yang

Cellular senescence is a stress response that irreversibly arrests cell proliferation and engages a complex senescence-associated secretory phenotype (SASP). The senescence growth arrest prevents the development of cancer by halting cells at risk for malignant transformation. The SASP, which comprises numerous cytokines, chemokines, growth factors, proteases and small metabolites, serves to optimize tissue repair and regeneration in the face of damage. Despite these beneficial effects, the SASP can be deleterious, especially when senescent cells are chronically present such as when they accumulate during aging and at sites of age-related pathology. In addition, persistent senescent cells can stimulate hyperplastic pathologies, including, ironically, cancer metastases. Recent findings using complex cell culture models and genetically modified mice have provided new insights into the dual nature of the senescence response. Together, these new results hold both enormous promise as well as formidable challenges to developing approaches for maintaining the beneficial effects, while minimizing the deleterious effects, of this complex stress response – with the ultimate goal of delaying or preventing a host of age-related diseases.Citation Format: Judith Campisi. The senescence response - yin and yang. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia ...
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Getting out of Cycle: G0 and Senescence: Oral Presentations - Invited Abstracts Source Type: research