Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis

CONCLUSION: The lack of evidence on which antiepileptic drug to use in PTS is surprising given the number of patients prescribed an antiepileptic drug therapy for TBI. On the basis of currently available Level III evidence, patients treated with either levetiracetam or phenytoin have similar incidences of early seizures after TBI. ABBREVIATIONS: ADE, adverse drug event AED, antiepileptic drug CI, confidence interval OR, odds ratio PTS, posttraumatic seizure TBI, traumatic brain injury
Source: Neurosurgery - Category: Neurosurgery Tags: Review Source Type: research