Should Levetiracetam or Phenytoin Be Used for Posttraumatic Seizure Prophylaxis? A Systematic Review of the Literature and Meta-analysis
CONCLUSION: The lack of evidence on which antiepileptic drug to use in PTS is surprising given the number of patients prescribed an antiepileptic drug therapy for TBI. On the basis of currently available Level III evidence, patients treated with either levetiracetam or phenytoin have similar incidences of early seizures after TBI.
ABBREVIATIONS: ADE, adverse drug event
AED, antiepileptic drug
CI, confidence interval
OR, odds ratio
PTS, posttraumatic seizure
TBI, traumatic brain injury
Source: Neurosurgery - Category: Neurosurgery Tags: Review Source Type: research
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