Cytokine Elevation in Sudden Death With Respiratory Syncytial Virus: A Case Report of 2 Children

In this report, we present 2 RSV-related deaths of children who were born at full-term and developed normally up to the age of 19 months. Their cardiopulmonary arrests occurred within half a day after the onset of symptoms, such as cough and high fever. Many postmortem examinations were performed to investigate their unexpected deaths. Histopathological examinations revealed extensive bronchiolitis and mild pneumonia accompanying airway obstruction. Immunostaining revealed the presence of the virus mainly in bronchial epithelia, but not in alveoli. Complete brain edema was prominent, and encephalopathy was developing. Blood tests revealed that the IL-6 level was elevated more than>200-fold above normal, despite a normal C-reactive protein level. Because IL-6 may reflect the severity of bronchial epithelial damage and contribute to brain edema, an extreme elevation of IL-6 may predict the risk for sudden death in children with RSV infection.
Source: PEDIATRICS - Category: Pediatrics Authors: Tags: Pulmonology, RSV Case Report Source Type: research

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Pneumonia is the most common cause of hospitalization for nursing home residents. When deciding whether to treat a resident in the nursing home or transfer to a hospital, it is important to consider risks of hospitalization, including significant functional decline. Little is known about the functional status outcomes of nursing home residents hospitalized for pneumonia.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Source Type: research
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Source: Caring for the Ages - Category: Health Management Tags: Journal Highlights Source Type: news
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Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
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Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
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Source: WebMD Health - Category: Consumer Health News Source Type: news
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