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Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target.

Dietary phytochemicals for possible preventive and therapeutic option of uterine fibroids: Signaling pathways as target. Pharmacol Rep. 2016 Oct 20;69(1):57-70 Authors: Islam MS, Segars JH, Castellucci M, Ciarmela P Abstract A growing interest has emerged on dietary phytochemicals to control diverse pathological conditions. Unfortunately, dietary phytochemical research in uterine fibroids is still under construction. Uterine fibroids/leiomyomas are benign tumors developing from the myometrium of the uterus in premenopausal women. They may occur in more than 70% of women, and approximately 25% of women show clinically significant symptoms. These include heavy and prolonged menstrual bleeding, pelvic pressure (urinary frequency, incontinence, and difficulty with urination), pelvic pain, pelvic mass, infertility, and reproductive dysfunction. Due to lack of medical treatments surgery has been definitive choice for fibroid management. Moreover, surgery negatively affects women's quality of life, and its associated cost appears to be expensive. The molecular mechanism of fibroids development and growth is not fully elucidated. However, accumulated evidence shows that several signaling pathways, including Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin are involved in the leiomyoma pathogenesis, indicating that they could serve as targets for prevention and/or treatment of this tumor. Therefore, in this review, we discuss the involvement of signaling pathw...
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rep Source Type: research

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Authors: Darabad MN, Mazloumi A, Saraji GN, Afshari D, Foroushani AR Abstract OBJECTIVES: Prolonged sitting with a flexed back and neck is recognized as being associated with an increased risk of neck and back pain disorders among overhead crane operators. The aim of this study was to compare back and head postures over a full shift of work between operators who experience back and neck pain, and healthy operators. METHODS: In a first phase, the prevalence of musculoskeletal symptoms was assessed using the Nordic questionnaire among 120 crane operators. Based on first phase results, 17 operators with back/neck ...
Source: Journal of Occupational Health - Category: Occupational Health Tags: J Occup Health Source Type: research
CONCLUSION: SSEH is a rare cause of paraplegia. Early radiological diagnosis is crucial for timely neurosurgical management and saving patient from permanent neurological deficit or a fatal outcome. PMID: 29047318 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
There are many different possible causes of shoulder blade pain. In this article, we take a look at some common ones and their treatment options.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news
Conclusion The defined indication criteria constitute a prerequisite for appropriate provision of TKA in patients with knee OA in Germany. In eligible patients, shared-decision making should eventually determine if TKA is performed or not. The next important steps are the implementation of the defined indication criteria, and the prospective investigation of predictors of success or failure of TKA in the context of routine care provision in Germany. PMID: 29050054 [PubMed - in process]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Authors: Homagk N, Jarmuzek T, Hofmann GO, Homagk L Abstract Spondylodiscitis is a rare but serious infection of the spine. Recognised methods of treatment include immobilisation and systemic antibiotics. However, available data for specific and recommendations for continuing treatment are also rare. The aim of the present study is the optimisation of the therapy of spondylodiscitis using a clinical pathway that depends on a classification of spondylodiscitis. From 1 October 1998 to 31 December 2013, a classification of the severity of spondylodiscitis was established, including specific treatment recommendations. ...
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
SATURDAY, Oct. 21, 2017 -- How much pain a woman feels after cesarean delivery may depend on the length of the incision, a new study suggests. Researchers assessed pain in nearly 700 women who gave birth via elective C-sections. Both short and long...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSIONS: In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis. PMID: 29051707 [PubMed]
Source: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders - Category: Orthopaedics Tags: Clin Med Insights Arthritis Musculoskelet Disord Source Type: research
OBJECTIVE: This review aims to examine the available literature on the epidemiology, pathophysiology, and treatment of burn-induced pain. METHODS: A search was conducted on the epidemiology of burn injury and treatment of burn pain utilizing the da...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Finished treating a 63 yo man unfavorable intermediate risk prostate cancer patient in May 2017. 7920 cGy standard volumes nothing special, 180 cGy per fraction w short term ADT. He started developing diarrhea after treatment, did ok with 2-3 immodium a day. In the last 3 weeks Imodium not doing much and hes been having 8-9 BM's a day, never had blood. He was having low pelvic pain as well, tolerable but on and off throughout the day. He went to ED and they got a CTAP. This showed an... Post Prostate Symptoms Question
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
Conclusions: The data demonstrate statistically superior clinical outcomes following lumbar microdiscectomy as measured by ODI and SF-12 (physical composite scale) and a lower rate of recurrent herniation with the use of a cAM tissue graft compared with traditional microdiscectomy.
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Primary Research Source Type: research
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