Chlamydia suis and Chlamydia trachomatis induce multifunctional CD4 T cells in pigs.

Chlamydia suis and Chlamydia trachomatis induce multifunctional CD4 T cells in pigs. Vaccine. 2016 Nov 25;: Authors: Käser T, Pasternak JA, Delgado-Ortega M, Hamonic G, Lai K, Erickson J, Walker S, Dillon JR, Gerdts V, Meurens F Abstract Chlamydia trachomatis infections are the most prominent bacterial sexually-transmitted disease world-wide and a lot of effort is put into the development of an effective vaccine. Pigs have been shown to be a valuable animal model for C. trachomatis vaccine development. The aim of this study was to decipher the T-cell-mediated immune response to chlamydial infections including C. trachomatis and C. suis, the chlamydia species naturally infecting pigs with a demonstrated zoonotic potential. Vaginal infection of pigs with C. suis and C. trachomatis lasted from 3 to 21days and intra-uterine infection was still present after 21days in 3 out of 5 C. suis- and 4 out of 5 C. trachomatis-inoculated animals and caused severe pathological changes. Humoral immune responses including neutralizing antibodies were found predominantly in response to C. suis starting at 14days post inoculation. The T-cell-mediated immune responses to C. trachomatis and C. suis-infections started at 7days post inoculation and consisted mainly of CD4(+) T cells which were either IFN-γ single cytokine-producing or IFN-γ/TNF-α double cytokine-producing T-helper 1 cells. IL-17-producing CD4(+) T cells were rare or completely absent. T...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research