I get by with help from my friends: Maintaining immune cells in head and neck cancer

(Medical University of South Carolina) In an article published Sept. 22, 2016 in Frontiers in Immunology, researchers at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center report that inhibiting prostaglandin production slows the progression of premalignant lesions to head and neck squamous cell carcinoma. Preclinical studies showed that treatment of premalignant lesions with indomethacin, a nonsteroidal anti-inflammatory drug similar to aspirin, increased the presence of immune cells and lessened tumor burden.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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AbstractThe study is aimed at establishing the purpose of tumour markers, their application, classification, diagnostic and therapeutic roles in the management of head and neck cancer. A literature review using Medline, Scopus, Google Scholar, the Cochrane Database of Systematic Reviews and the Cochrane central register of controlled trials for articles published between 1993 and 2016 on tumour markers and their role in head and neck cancer was performed. A broader search of prognostic markers in head and neck cancer was also carried out to avoid missing other pertinent markers. Natural history, tumour biology, stage and p...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
Abstract Recent reports describe how genome-wide transcriptional analysis of cancer tissues can be exploited to identify molecular signatures of immune infiltration in cancer. We hypothesize that immune infiltration in cancer may also be defined by changes in certain epigenetic signatures. In this context, a primary objective is to identify site-specific CpG markers whose levels of methylation may be highly indicative of known transcriptional markers of immune infiltration such as GZMA, PRF1, T cell receptor genes, PDCD1, and CTLA4. This has been accomplished by integrating genome-wide transcriptional expression a...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
Conclusion.IC with Genexol‐PM and cisplatin demonstrated modest tumor response with well‐tolerated toxicity profiles for patients with LA‐HNSCC.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Head and Neck Cancers, Chinese Edition, Clinical Trial Results Source Type: research
Authors: Liang Y, Feng G, Zhong S, Gao X, Tong Y, Cui W, Huang G, Zhang Z, Zhou X Abstract BACKGROUND Chemokines are important in inflammation, immunity, tumor progression, and metastasis. The purpose of this research was to find an integrated-RNA signature of chemokine family genes to predict the survival prognosis in head and neck squamous carcinoma (HNSC) patients. MATERIAL AND METHODS Relevant data of 504 HNSC patients were extracted from The Cancer Genome Atlas (TCGA) database. Through analyzing RNA sequencing data, the univariate Cox model was used to identify chemokine family genes associated with survival a...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Abstract Many tumors including head and neck squamous cell carcinoma (HNSCC) spread along the lymphatic network. Current imaging modalities can only detect sufficiently large metastases. Therefore, adjacent lymph node levels (LNL) are irradiated electively since they may harbor microscopic tumor. We apply Bayesian Networks (BN) to model lymphatic tumor progression. The model can subsequently be used to personalize the risk estimation of microscopic lymph node metastases in newly diagnosed patients based on their distribution of macroscopic metastases. A BN is a graphical representation of a joint probability distr...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
ConclusionAt least a quarter of HNSCC patients go on to develop a metachronous second primary. These are of poor prognosis, whatever their location.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
ConclusionsIL1RN is downregulated in oral dysplasia and oral cancer. How this downregulation favours oral carcinogenesis it is not yet known, but might be related with the oral senescence program.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionIn tumour progression, several cellular pathways may be affected by a single microRNA since it can target multiple mRNAs. Much more light is to be shed by developing as well as by tracking the identified microRNA signatures in oral squamous cell carcinoma, to pave the way for their future clinical use in the diagnosis, management, and prognosis.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsActivation of Wnt/β-catenin signaling pathway is an early event in HNSCC carcinogenesis. Lineage tracing using the Axin2-CreER reporter may link TICs properties with a fundamental signaling pathway in normal development. Further research is required to clarify the role of Wnt-responsive TICs in recurrence and therapy resistance of HNSCC.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
MEC is the most common salivary gland malignancy. Although prognosis is mostly based on TNM status, histologic grade is also used as a parameter to determine treatment. CAFs have been reported to influence worse behavior in several malignancies including head and neck squamous cell carcinoma. We noticed the presence of CAF-like cells, displaying immunohistochemical positivity for alpha smooth muscle actin, in some MECs with bad outcome and we hypothesize that CAFs may influence MEC aggressiveness.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: #52 Source Type: research
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