Repression of telomere-associated genes by microglia activation in neuropsychiatric disease.
Repression of telomere-associated genes by microglia activation in neuropsychiatric disease.
Eur Arch Psychiatry Clin Neurosci. 2016 Nov 28;
Authors: Kronenberg G, Uhlemann R, Schöner J, Wegner S, Boujon V, Deigendesch N, Endres M, Gertz K
Abstract
Microglia senescence may promote neuropsychiatric disease. This prompted us to examine the relationship between microglia activation states and telomere biology. A panel of candidate genes associated with telomere maintenance, mitochondrial biogenesis, and cell-cycle regulation were investigated in M1- and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models of stroke, Alzheimer's disease, and chronic stress. M1 polarization, ischemia, and Alzheimer pathology elicited a strikingly similar transcriptomic profile with, in particular, reduced expression of murine Tert. Our results link classical microglia activation with repression of telomere-associated genes, suggesting a new mechanism underlying microglia dysfunction.
PMID: 27896432 [PubMed - as supplied by publisher]
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
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