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The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection

This article reviews the findings within the field of omics relevant to LB and its prospective utility in developing an array of biomarkers that can be employed in LB diagnosis and detection particularly at the early disease stages.
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research

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Children with Lyme meningitis are often treated with intravenous ceftriaxone, although oral doxycycline may be effective. Parents were surveyed after observing a video describing a hypothetical Lyme meningitis treatment trial. Eighty-four of 102 (82%) would consent to their child participating. Parents would accept 2 additional days of symptoms (noninferiority margin) with doxycycline even if ceftriaxone hastened symptom resolution.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Rheumatology News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Yorkshire ’s Jurassic World, at the Yorkshire Museum, includes a pregnant ichthyosaur, a Mesozoic virtual reality experience, and a dinosaur called AlanIf you say the word Jurassic to people in the UK, the chances are that their first thoughts will be of a certain hugely successful film franchise. Most palaeontologists are fine with this, because it gives us an excuse to wheel out our well-honed “all the things that were wrong about the Jurassic Park film” material. If they mention anything else at all, it is likely to be the Jurassic coast, a fantastic piece of tourism branding which ensures that Dorset ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Fossils Geology Dinosaurs Source Type: news
Condition:   Lyme Disease Intervention:   Device: Transcranial Direct Current Stimulator Sponsor:   Spaulding Rehabilitation Hospital Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy of B. burgdorferi, orchestrated by a surface protein annotated as BBA57, through its...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Conclusions: Clinical isolates of B. miyamotoi are highly susceptible to doxycycline, azithromycin and ceftriaxone in vitro Interestingly, as earlier described for tick isolates, amoxicillin shows poor in vitro activity against clinical B. miyamotoi isolates. PMID: 29661882 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Lyme disease is the most frequently reported zoonotic tick-borne disease worldwide, and the number of infected humans is increasing. Lyme disease (or Lyme borreliosis) is an affection caused by the spirochete Borrelia burgdorferi, sensu lato. Lyme disease is also reported as a variety of misleading clinical symptomatologies. Infected patient ’s blood serology is the most currently test used for its diagnosis. However, serology has a low sensitivity, which ranges from 34 % to 70%.Thus, there are numerous subsequent false-negative diagnoses despite an active clinical infection profile.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research
Particularly in Brazil, cases with Lyme-like clinical symptoms, locally known as the Baggio-Yoshinari syndrome, have been diagnosed since 1992; however, the epidemiological, clinical and laboratory findings of this syndrome differ from the classic cases of Lyme borreliosis and the etiological agent has not yet been isolated either from humans or a natural vector [1].
Source: Travel Medicine and Infectious Disease - Category: Infectious Diseases Authors: Source Type: research
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