The Potential of Omics Technologies in Lyme Disease Biomarker Discovery and Early Detection
This article reviews the findings within the field of omics relevant to LB and its prospective utility in developing an array of biomarkers that can be employed in LB diagnosis and detection particularly at the early disease stages.
Children with Lyme meningitis are often treated with intravenous ceftriaxone, although oral doxycycline may be effective. Parents were surveyed after observing a video describing a hypothetical Lyme meningitis treatment trial. Eighty-four of 102 (82%) would consent to their child participating. Parents would accept 2 additional days of symptoms (noninferiority margin) with doxycycline even if ceftriaxone hastened symptom resolution.
Reuters Health Information
Yorkshire ’s Jurassic World, at the Yorkshire Museum, includes a pregnant ichthyosaur, a Mesozoic virtual reality experience, and a dinosaur called AlanIf you say the word Jurassic to people in the UK, the chances are that their first thoughts will be of a certain hugely successful film franchise. Most palaeontologists are fine with this, because it gives us an excuse to wheel out our well-honed “all the things that were wrong about the Jurassic Park film” material. If they mention anything else at all, it is likely to be the Jurassic coast, a fantastic piece of tourism branding which ensures that Dorset ...
Condition: Lyme Disease Intervention: Device: Transcranial Direct Current Stimulator Sponsor: Spaulding Rehabilitation Hospital Suspended
Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy of B. burgdorferi, orchestrated by a surface protein annotated as BBA57, through its...
Conclusions: Clinical isolates of B. miyamotoi are highly susceptible to doxycycline, azithromycin and ceftriaxone in vitro Interestingly, as earlier described for tick isolates, amoxicillin shows poor in vitro activity against clinical B. miyamotoi isolates. PMID: 29661882 [PubMed - as supplied by publisher]
Lyme disease is the most frequently reported zoonotic tick-borne disease worldwide, and the number of infected humans is increasing. Lyme disease (or Lyme borreliosis) is an affection caused by the spirochete Borrelia burgdorferi, sensu lato. Lyme disease is also reported as a variety of misleading clinical symptomatologies. Infected patient ’s blood serology is the most currently test used for its diagnosis. However, serology has a low sensitivity, which ranges from 34 % to 70%.Thus, there are numerous subsequent false-negative diagnoses despite an active clinical infection profile.
Particularly in Brazil, cases with Lyme-like clinical symptoms, locally known as the Baggio-Yoshinari syndrome, have been diagnosed since 1992; however, the epidemiological, clinical and laboratory findings of this syndrome differ from the classic cases of Lyme borreliosis and the etiological agent has not yet been isolated either from humans or a natural vector .