Secondary hemophagocytic lymphohistiocytosis (HLH) from a presumed brown recluse spider bite - Dandoy C, Grimley M.

Systemic loxoscelism is a rare complication after Loxosceles reclusa (brown recluse spider) envenomation. Loxosceles venom contains pro-inflammatory proteins, which have been shown to be elevated in patients with hemophagocytic lymph histiocytosis. We pres...
Source: SafetyLit: All (Unduplicated) - Category: Global & Universal Tags: Non-Human Animals and Insects Source Type: news

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Langerhans cell histiocytosis (LCH) is an uncommon hematologic condition resulting from neoplastic proliferation of antigen-presenting cells with characteristics of Langerhans cells. These cells can accumulate in many organs including skin, bone, liver, brain and lung. Bone lesions are reported in 80% of cases of LCH. A diagnosis is made via histopathological analysis of lesions. LCH may present with single-system or multi-system lesions and lesions may be unifocal or multifocal. It is more common in children than adults.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Publication date: March–April 2020Source: Brazilian Journal of Otorhinolaryngology, Volume 86, Issue 2Author(s): Onur Ismı, Rabia Bozdogan Arpaci, Anıl Ozgur, Elvan Caglar Citak, Neslihan Eti, Tugce Puturgeli, Yusuf Vayisoglu
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Conditions:   Hematopoietic and Lymphoid Cell Neoplasm;   Recurrent Ependymoma;   Recurrent Ewing Sarcoma;   Recurrent Hepatoblastoma;   Recurrent Histiocytic and Dendritic Cell Neoplasm;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Lymphoma;   Recurrent Malignant Germ Cel l Tumor;   Recurrent Malignant Glioma;   Recurrent Malignant Solid Neoplasm;   Recurrent Medulloblastoma;   Recurrent Neuroblastoma;   Recurr...
Source: - Category: Research Source Type: clinical trials
We report 11 children with vertebral lesion of Langerhans cell histiocytosis (LCH) diagnosed and treated between 2000 and 2015. Vertebral lesions were usually present at LCH diagnosis. No child developed neurologic symptoms. Among 29 vertebral lesions, only 2 were unstable. Chemotherapy was used in all children but 3. A LCH recurrence was observed in 6 patients, involving vertebrae in 4 cases. All children were disease-free at their last follow-up. Sequelae were more often radiologic than clinical. Since potential recurrences and incomplete bone regeneration exist, discussion about optimal treatment and long-term follow-up...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research
We describe an 18-year-old woman with several month's history of a 12 x 7 mm palpable mammary nodule, that was hypoechoic, with regular margins and vascularization areas by ultrasound. A fibroadenoma was hypothesized (American College of Radiology BI-RADS 3). A 14 G needle biopsy was performed, showing a LC proliferation suspected for LCH of a lymph node, with florid dermatopathic lymphadenopathy in differential diagnosis. The multidisciplinary team of the breast clinic decided to perform a lumpectomy and a diagnosis of LCH involving an intra-mammary lymph node was made. Langerhans cells (LC) are dendritic cells characteri...
Source: Pathologica - Category: Pathology Tags: Pathologica Source Type: research
We report here findings of a series of FDG PET/CT scans during the course of clofarabine therapy in a 12-year-old girl with extracutaneous juvenile xanthogranuloma.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Erdheim-Chester disease (ECD) is a rare, non-Langerhans histiocytosis characterized by xanthogranulomatous infiltration typically affecting long bones, cardiovascular system, retroperitoneum, and lung, and that involves the CNS in 25%–50% of patients (table).1,2 Historically, establishing the diagnosis has been challenging, particularly in the absence of systemic abnormalities. Recent genomic studies have uncovered that approximately 50% of ECD tissue samples harbor a mutation in the BRAF gene,3 termed BRAFV600E, and that pointed to a neoplastic, rather than inflammatory, nature of the disease.4,5
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Clinical Neurology, All Medical/Systemic disease, All Oncology, Primary brain tumor, Chemotherapy-tumor Clinical/Scientific Notes Source Type: research
The clinical significance of the BRAFV600E mutation in adult Langerhans cell histiocytosis (LCH), including pulmonary Langerhans cell histiocytosis (PLCH), is not well understood. Similarly, the spectrum of molecular alterations involved in adult LCH has not been fully delineated. To address these issues, we genotyped a large number of adult LCH biopsies and searched for an association of identified molecular alterations with clinical presentation and disease outcome. Biopsies from 117 adult LCH patients, 83 with PLCH (median age 36.4 years, 56 females, 38 multisystem disease, 79 single system disease, 65 current smok...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Rare lung disease Source Type: research
Conditions:   Ectomesenchymoma;   Recurrent Adrenal Gland Pheochromocytoma;   Recurrent Ependymoma;   Recurrent Ewing Sarcoma;   Recurrent Hepatoblastoma;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Malignant Germ Cell Tumor;   Recurrent Malignant Glioma;   Recurrent Medull oblastoma;   Recurrent Melanoma;   Recurrent Neuroblastoma;   Recurrent Non-Hodgkin Lymphoma;   Recurrent Osteosarcoma;   Recurrent Peripheral Primitive Neuroectode...
Source: - Category: Research Source Type: clinical trials
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