Cytoplasmic MSH2 immunoreactivity in a patient with Lynch syndrome with an EPCAM –MSH2 fusion

ConclusionsThe unusual cytoplasmic immunoreactivity of MSH2 was considered to be attributable to the non‐functional EPCAM–MSH2 fusion product. The present case illustrates that not only loss of expression, but also abnormal localization, of MMR proteins is indicative of a defective MMR system.

Source: Histopathology - November 27, 2016 Category: Pathology Authors: Shigeki Sekine, Reiko Ogawa, Shinya Saito, Mineko Ushiama, Dai Shida, Takeshi Nakajima, Hirokazu Taniguchi, Nobuyoshi Hiraoka, Teruhiko Yoshida, Kokichi Sugano Tags: Case Report Source Type: research