Reply Should Histologic Determination of Amyloid Load Determine Management Decisions in Light-Chain Amyloidosis?

Thank you for giving us the opportunity to respond to the comments of Dr. Ruberg and colleagues regarding our paper(1). They raise some concerns and propose that cardiac magnetic resonance (CMR) with extracellular volume (ECV) determination yields a “truer average” of amyloid load of the entire heart, and that ECV has been shown to strongly correlate with N-terminal pro−brain natriuretic peptide. However, these data were not shown in the referenced paper(2). Dr. Ruberg and colleagues also failed to mention that ECV is based on only 1 short- and 1 long-axis view. Thus, ECV does not reflect the entire heart.
Source: Journal of the American College of Cardiology - Category: Cardiology Source Type: research