Enzyme's'editing' preferences have implications for infertility, cancer
To " turn off " particular regions of genes or protect them from damage, DNA strands can wrap around small proteins, called histones, keeping out all but the most specialized molecular machinery. Now, new research shows how an enzyme called KDM4B " reads " one and " erases " another so-called epigenetic mark on a single histone protein during the generation of sex cells in mice. The researchers say the finding may one day shed light on some cases of infertility and cancer.
Arcangelo Barbonetti, Alessio Martorella, Elisa Minaldi, Settimio D'Andrea, Dorian Bardhi, Chiara Castellini, Felice Francavilla, Sandro Francavilla
Conclusion The efficacy of fertility preservation procedures in females with TS is still unknown. Future studies with focus on efficacy, safety and long-term follow-up are desperately needed. PMID: 30888127 [PubMed - in process]
Infertility in women is associated with a higher risk of developing cancer, though the absolute risk is very low, at 2%, researchers say.Reuters Health Information
Abstract SummaryCryptorchidism, characterized by the presence of one (unilateral) or both (bilateral) undescended testes, is a common male urogenital defect. Cryptorchidism can lead to male infertility, testicular cancer being the most extreme clinical symptom, as well as psychological issues of the inflicted individual. Despite this, both knowledge about the aetiology of cryptorchidism and the mechanism for cryptorchidism-induced male infertility remain limited. In this present study, by using an artificial cryptorchid mouse model, we investigated the effects of surgery-induced cryptorchidism on spermatogenic cel...
A study, published inHuman Reproduction, reports that women with fertility issues have a higher risk of developing cancer.Daily Mail
Overall risk higher for developing cancer; increased risks seen for uterine, ovarian, lung, thyroid cancers
Abstract: Evidence suggests that there are important interactions between HIV and female genital schistosomiasis (FGS) that may have significant effects on individual and population health. However, the exact way they interact and the health impacts of the interactions are not well understood. In this article, we discuss what is known about the interactions between FGS and HIV, and the potential impact of the interactions. This includes the likelihood that FGS is an important health problem for HIV-positive women in Schistosoma-endemic areas potentially associated with an increased risk of mortality, cancer, and infertil...
ConclusionsWhile awaiting replication of this study in larger populations, these findings challenge the presumed dominant importance of genetic parenthood. This raises questions about whether donor gametes could be presented as a worthy alternative earlier in treatment trajectories and whether investments in novel treatments enabling genetic parenthood, like in vitro gametogenesis, are proportional to their future clinical impact.
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