Enzyme's 'editing' preferences have implications for infertility and cancer

(Johns Hopkins Medicine) To 'turn off' particular regions of genes or protect them from damage, DNA strands can wrap around small proteins, called histones, keeping out all but the most specialized molecular machinery. Now, new research shows how an enzyme called KDM4B 'reads' one and 'erases' another so-called epigenetic mark on a single histone protein during the generation of sex cells in mice. The researchers say the finding may one day shed light on some cases of infertility and cancer.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Discussion Cryptorchidism is the failure of one or both testes to descend from the abdomen into the scrotum. Congenital undescended testis (UDT)is common in young infants (1-4% in term infants and 45% in preterm infants) in that the testes will be palpable but remain high, but most testes will descend by 3-6 months and by 9 months of age only 1% remain undescended. The scrotum often appears underdeveloped. Sometimes the testes cannot be identified and is intra-abdominal at birth. Intra-abdominal testes are less likely to migrate to the scrotum and therefore are more likely to remain undescended. Acquired undescended test...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Scientists may soon be able to create human sperm and eggs using ordinary cells – a boon for those with fertility problems that raises troubling ethical questionsForty years ago, couples suffering from infertility were given hope by the birth of Louise Brown, the first “test-tube baby”. But although millions of babies have now been born by IVF, the technique can offer no help to couples eager to have a child that is genetically theirs but who lack the eggs or sperm to make it: men whose testes produce no sperm, say, or women who have undergone surgery for ovar ian cancer. Some opt for donor eggs or sperm,...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Genetics Reproduction Fertility problems IVF Biology Science Health Society Source Type: news
Publication date: Available online 10 October 2018Source: Trends in GeneticsAuthor(s): Aaron C. Goldstrohm, Traci M. Tanaka Hall, Katherine M. McKenneyMammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory networks, biological functions, and relevance to diseases. Pumilio proteins bind an extensive network of mRNAs and repress protein expression by inhibiting translation and promoting mRNA decay. Opposingly, in certain contexts, they can activate protein expression. Pumilio proteins also regulate noncoding (...
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research
Researchers from Harvard found that '3-Free' polishes that claim to be free of the 'toxic trio' - DnBP, toluene and formaldehyde - often still contain toxins linked to brain toxicity and even foetal abnormalities.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Lots of infertility clinics call themselves infertility clinics because they treat infertile patients, and this makes a lot of sense. After all, cancer specialists treat cancer, and cardiologists treat patients with heart disease, so this is quite reasonable.One the other hand, a lot of infertile patients object to this . They say that these are pro-fertility clinics, because they are helping patients to have a baby . Since they promote fertility, why do they continue to use such a negative name ? Why not call them fertility clinics or pro-fertility clinics – wouldn’t this be much more positive and hopeful...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
ConclusionThis study is at the best of our knowledge the first nationwide survey to assess the state of the art in oncofertility management. It highlights inadequate management of fertility preservation for female patients in France. Physicians reported lacking knowledge and tools that would allow them to provide patients with appropriate information. A better collaboration between cancer and fertility centers needs to be organized in France as already organized in other countries.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Infertility has long-term effects beyond the inability to conceive. Infertility may be a harbinger of future disease and altered longevity. Understanding the mechanisms of how fertility is a window to health opens new avenues of important investigation addressing interdependent physiologic processes. Identification of healthy persons at risk for future cardiovascular disease, diabetes, or cancer could allow a change in reproductive medical care by altering long-term surveillance and reduction of risk.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Views and reviews Source Type: research
Authors: Newton CL, Riekert C, Millar RP Abstract Dysregulation at any level of the Hypothalamic-Pituitary-Gonadal (HPG) axis results in, or aggravates, a number of hormone-dependent diseases such as delayed or precocious puberty, infertility, prostatic and ovarian cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, endometriosis, uterine fibroids, lean body mass, as well as metabolism and cognitive impairment. As gonadotropin-releasing-hormone (GnRH) is an essential regulator of the HPG axis, agonist and antagonist analogs are efficacious in the treatment of these conditions. GnRH analogs also play ...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
It can be very scary to go through your first IVF cycle because you don't know what to expect. You try to do your homework , so you can be better prepared, but you get completely confused by all the contradictory and conflicting information you get – and this true, whether it comes from family members or from online sources. Friends will share all kinds of horror stories about how someone’s aunt got cancer after doing IVF; or how a family member once told them about a cousin who put on 10 kg after doing an IVF cycle. A lot of this second i nformation is based on hearsay and is unreliable, you're never sure...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Conditions:   Cancer;   Hematologic Disorder;   Infertility;   Ovarian Failure Intervention:   Other: Ovarian Cryopreservation Sponsor:   St. Justine's Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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