Enzyme's 'editing' preferences have implications for infertility and cancer

(Johns Hopkins Medicine) To 'turn off' particular regions of genes or protect them from damage, DNA strands can wrap around small proteins, called histones, keeping out all but the most specialized molecular machinery. Now, new research shows how an enzyme called KDM4B 'reads' one and 'erases' another so-called epigenetic mark on a single histone protein during the generation of sex cells in mice. The researchers say the finding may one day shed light on some cases of infertility and cancer.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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New approach could preserve fertility for boys having cancer treatment, say scientists.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Arcangelo Barbonetti, Alessio Martorella, Elisa Minaldi, Settimio D'Andrea, Dorian Bardhi, Chiara Castellini, Felice Francavilla, Sandro Francavilla
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusion The efficacy of fertility preservation procedures in females with TS is still unknown. Future studies with focus on efficacy, safety and long-term follow-up are desperately needed. PMID: 30888127 [PubMed - in process]
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Baby monkey is first primate created using sperm from tissue transplanted into dad, Published online: 21 March 2019; doi:10.1038/d41586-019-00938-9The technique could help boys made infertile by cancer treatment to become fathers later in life.
Source: Nature AOP - Category: Research Authors: Source Type: research
AbstractInfertility associated with cancer can have significant psychological impacts for cancer patients and survivors, necessitating appropriate fertility ‐related psychological support. This literature review details the psychological impact of infertility in cancer patients and survivors, and discusses fertility counseling as described in current international guidelines; as either the provision of fertility information or psychosocial support. Fe rtility counseling has a role in assisting with fertility treatment decision‐making, but also in supporting patients with the emotional distress associated with potential...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: REVIEW Source Type: research
Infertility in women is associated with a higher risk of developing cancer, though the absolute risk is very low, at 2%, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Abstract SummaryCryptorchidism, characterized by the presence of one (unilateral) or both (bilateral) undescended testes, is a common male urogenital defect. Cryptorchidism can lead to male infertility, testicular cancer being the most extreme clinical symptom, as well as psychological issues of the inflicted individual. Despite this, both knowledge about the aetiology of cryptorchidism and the mechanism for cryptorchidism-induced male infertility remain limited. In this present study, by using an artificial cryptorchid mouse model, we investigated the effects of surgery-induced cryptorchidism on spermatogenic cel...
Source: Zygote - Category: Reproduction Medicine Authors: Tags: Zygote Source Type: research
A study, published inHuman Reproduction, reports that women with fertility issues have a higher risk of developing cancer.Daily Mail
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Overall risk higher for developing cancer; increased risks seen for uterine, ovarian, lung, thyroid cancers
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Gynecology, Oncology, Journal, Source Type: news
Abstract: Evidence suggests that there are important interactions between HIV and female genital schistosomiasis (FGS) that may have significant effects on individual and population health. However, the exact way they interact and the health impacts of the interactions are not well understood. In this article, we discuss what is known about the interactions between FGS and HIV, and the potential impact of the interactions. This includes the likelihood that FGS is an important health problem for HIV-positive women in Schistosoma-endemic areas potentially associated with an increased risk of mortality, cancer, and infertil...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Critical Review Source Type: research
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