Clinical efficacy of sublingual immunotherapy in the second treated year for 133 patients with japanese cedar pollinosis in 2016.
CONCLUSION: SLIT in the second treated year showed good clinical efficacy in reducing symptoms and SMS of JCP, and in improving QOL. SLIT was significantly effective compaired with other pharmacotherapies. PMID: 27885205 [PubMed - in process]
ConclusionAlthough a larger number of patients for a longer follow ‐up period are needed to precisely assess the treatment efficacy, AIT using cat and/or dog dander may be an effective treatment option for AD patients, especially for severe AD patients with other respiratory allergic comorbidities who cannot completely avoid the exposure to animal dander.
Purpose of review In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases. Recent findings Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex assays, mainly performed through microarrays or macroarrays. It is important to collect both results from specific IgE toward allergen extracts and toward molecular allergens, to collect the most complete information o...
ConclusionAn increase of IL6 and IL12 in cAC was found in the studied population. These two cytokines may be potential immunotherapy targets cAC classification.
Abstract BACKGROUND: As part of the planning for a future multicenter study, this preliminary clinical trial was performed to explore candidate biomarkers useful for predicting the therapeutic effects of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis (JCP) using serum samples from patients. METHODS: This prospective study included patients undergoing SLIT for JCP at our hospital. All enrolled patients (n = 17) started SLIT between June and November of 2015. With informed consent from the patients, in January, March, and June of 2016, blood samples were obtained, and an inquiry was conducted usi...
An international, double-blind, placebo-controlled trial evaluated the efficacy and safety of ragweed sublingual immunotherapy (SLIT)-tablets in children with allergic rhinitis with or without conjunctivitis (AR/C). Asthma outcomes were assessed as exploratory endpoints.
Birch, alder, hazel, and oak are members of the birch homologous group based on IgE cross-reactivity to the major allergen Bet v 1. Treatment effects of tree sublingual immunotherapy (SLIT)-tablets containing standardized birch pollen extract in participants with birch pollen-induced allergic rhinitis with or without conjunctivitis (AR/C) were evaluated during alder/hazel and oak pollen seasons.
Ragweed sublingual immunotherapy (SLIT)-tablets improve symptoms and decrease medication use in adults with allergic rhinitis with or without conjunctivitis (AR/C) during peak pollen season when symptoms are most burdensome and throughout the entire season. The efficacy and safety of ragweed SLIT-tablets during the peak and entire season were evaluated in children.
New pediatric data now allows for comparison of treatment-induced serological immune responses to ragweed sublingual immunotherapy (SLIT)-tablets between children and adults with allergic rhinitis with or without conjunctivitis (AR/C).
ConclusionsPooled data indicate that short- and long-term timothy grass SLIT-tablet is well tolerated in children, regardless of geographic region. AEs were generally local, mild, and transient allergic reactions.
Subcutaneous immunotherapy (SCIT) is effective for allergic rhinitis and conjunctivitis, asthma, and insect venom hypersensitivity. The risk of severe allergic reactions induced by SCIT remains low, and mild systemic reactions have recently shown a tendency to decline. However, near-fatal and fatal anaphylactic reactions may occur. Clinicians administering allergen-specific immunotherapy should receive specialized training and be aware of risk factors and preventive measures to avoid severe allergic reactions induced by SCIT.