Fibroblasts and macrophages: Key players in the head and neck cancer microenvironment

Conclusion CAFs can promote HNSCC progression through direct contact and/or paracrine signaling. Interactions between HNSCC cells and CAFs stimulate expression of various growth factors, cytokines, chemokines, MMPs, and periostin. TAMs in HNSCC upregulate the production of IL-1β, IL-10, and MIP-3α/CCL20, which are involved in tumorigenic processes. Graphical abstract
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research