Mutations in embB gene associated with resistance to ethambutol in Mycobacterium tuberculosis strains isolated from TB patients in the west of Iran (2014 –15)

Conclusion Our results were similar to those that were regularly reported in earlier studies. The only mutations in the EMB-resistant isolates were found in embB 306 and 406 codons. Substantiation amino acids at codon 306 were the most frequent. The data indicated that embB 306 mutations are sufficient to induce ethambutol resistance, and detection of these mutations is advisable to be considered in the development of rapid molecular tests. Sequence analysis of the ERDR in the embB gene is adequate for rapid detection of EMB resistance, and mutations in the codon 306 are good predictive markers for resistance to EMB.
Source: International Journal of Mycobacteriology - Category: Infectious Diseases Source Type: research