Increased expression of efflux pump genes in extensively drug-resistant isolates of Mycobacterium tuberculosis

Conclusion The differences between XDR-TB and drug-susceptible isolates suggest that the increased expression levels of MTB efflux pump genes may contribute to drug resistance in extensively drug-resistant tuberculosis. Future studies are needed to determine whether combining efflux pump inhibitors to antitubercular drugs would be effective to treat resistant tuberculosis.
Source: International Journal of Mycobacteriology - Category: Infectious Diseases Source Type: research