Needleless coaxial electrospinning: A novel approach to mass production of coaxial nanofibers

Publication date: 10 January 2017 Source:International Journal of Pharmaceutics, Volume 516, Issues 1–2 Author(s): Lucie Vysloužilová, Matej Buzgo, Pavel Pokorný, Jiří Chvojka, Andrea Míčková, Michala Rampichová, Jiří Kula, Karel Pejchar, Martin Bílek, David Lukáš, Evžen Amler Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering. Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research