The Challenge of Primary Central Nervous System Lymphoma

Publication date: December 2016 Source:Hematology/Oncology Clinics of North America, Volume 30, Issue 6 Author(s): Julia Carnevale, James L. RubensteinTeaser Primary central nervous system (CNS) lymphoma is a challenging subtypes of aggressive non-Hodgkin lymphoma. Emerging clinical data suggest that optimized outcomes are achieved with dose-intensive CNS-penetrant chemotherapy and avoiding whole brain radiotherapy. Anti-CD20 antibody-based immunotherapy as a component of high-dose methotrexate-based induction programs may contribute to improved outcomes. An accumulation of insights into the molecular and cellular basis of disease pathogenesis is providing a foundation for the generation of molecular tools to facilitate diagnosis as well as a roadmap for integration of targeted therapy within the developing therapeutic armamentarium for this challenging brain tumor.
Source: Hematology Oncology Clinics of North America - Category: Hematology Source Type: research