All about Oxy
RX PAD With the death of the entertainer Prince attributed to a fentanyl overdose, and new FDA warnings, opioids have been making headlines. Since the most common reason patients visit the emergency department is for pain, it is not surprising that emergency physicians prescribe and administer medications such as oxycodone on a daily basis. Here are some of the basics about how oxycodone works, and also the reason why chronic users may be at even higher risk of unexpected respiratory depression. HOW IT WORKS: Oxycodone is a semi-synthetic opioid with analgesic properties. Oxycodone binds to mu, kappa, and delta opioid receptors in the central nervous system, causing inhibition of ascending pain pathways, alteration of pain perception, and producing generalized CNS depression. The mechanism is complex, but likely involves inhibition of the adenyl cyclase system, causing a fall in cyclic AMP, decreased release of neurotransmitters, and subsequent reduced transmission of nerve stimulation.1 Onset of action is within 10–15 minutes of administration, and the half-life is 3–4 hours for immediate-release oxycodone, and 12 hours for extended-release oxycodone (sold as OxyContin, reformulated to be more tamper-resistant in 2010). Oxycodone is commonly supplied as a combination product with acetaminophen (sold as Percocet, Roxicet and others). MAJOR INDICATIONS: Oxycodone is indicated for severe pain not responsive to non-opioid medications, including severe cancer a...
Publication date: Available online 9 July 2020Source: Neurophysiologie CliniqueAuthor(s): Elif Uygur-Kucukseymen, Luis Castelo-Branco, Kevin Pacheco-Barrios, Maria Alejandra Luna-Cuadros, Alejandra Cardenas-Rojas, Stefano Giannoni-Luza, Huiyan Zeng, Anna Carolyna Gianlorenco, Marina Gnoatto-Medeiros, Emad Salman Shaikh, Wolnei Caumo, Felipe Fregni
Publication date: 1 August 2020Source: Neuroscience, Volume 440Author(s): Katsumasa Muneoka, Yasunori Oda, Masaaki Iwata, Masaomi Iyo, Kenji Hashimoto, Yukihiko Shirayama
In this study, we investigated the antitumor activity of H2Mab-19 in an LN229 glioblastoma xenograft model. H2Mab-19 showed high binding affinity (KD: 1.1 × 10-8 M) against LN229 cells. Furthermore, H2Mab-19 significantly reduced tumor development in an LN229 xenograft. These results suggest that treatment with H2Mab-19 may be a useful therapy for patients with HER2-expressing glioblastomas. PMID: 32644843 [PubMed - as supplied by publisher]
Publication date: Available online 9 July 2020Source: Meat ScienceAuthor(s): Carolina L. Gonzales, Ty E. Lawrence, John P. Hutcheson, Stephen B. Smith
Publication date: November 2020Source: Food Research International, Volume 137Author(s): Priya Tyagi, Mohd Tasleem, Shweta Prakash, Garima Chouhan
AbstractTo evaluate the efficacy and safety of holmium laser enucleation of prostate (HoLEP) for treating urinary retention in patients with advanced prostate cancer. Thirty-eight cases of advanced prostate cancer with urinary retention were enrolled in this retrospective study. All the 38 patients were treated with CAB as a basis. Among them, 21 cases chose HoLEP additionally (HoLEP group). Seventeen cases stuck to CAB alone (CAB group). Serum PSA level, International Prostate Symptom Score (IPSS), quality of life score (QoLs), maximal flow rate (Qmax), and post-void residual volume (PVR) at 3, 6, 12, and 18 months after ...
CONCLUSION: The preventive strategy is fundamental, since the therapy is complex with poorly validated effectiveness. PMID: 32645129 [PubMed - as supplied by publisher]
CONCLUSIONS: We believe that ADH will decrease with experience and meticulous preoperative clinical and radiological evaluations. Abandoning the donor hepatectomy is always a valid option at any stage of the surgery when the unexpected is encountered. PMID: 32644313 [PubMed - as supplied by publisher]
CONCLUSION: Core needle biopsy and receptor analysis should be considered on the positive axillary nodes in breast cancer patients. Adjuvant treatment should be targeted to the receptor profile of the lymph node metastases. PMID: 32644312 [PubMed - as supplied by publisher]
Authors: Mbanje C, Mungazi SG, Muchuweti D, Mazingi D, Mlotshwa M, Maunganidze AJV Abstract BACKGROUND: Ileo-sigmoid knotting is a rare cause of intestinal obstruction with a rapidly progressive course, for which expedient surgical intervention is required to prevent mortality. The aim of this study was to determine the characteristics, presentation, morbidity and mortality associated with ileo-sigmoid knotting at Parirenyatwa Group of Hospitals (PGH). To determine the preoperative diagnostic precision and management patterns of ileo-sigmoid knotting cases at PGH. METHODS: A retrospective analysis was performed...
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