The magnitude of change in the fetal cerebroplacental ratio in the third trimester and the risk of adverse pregnancy outcome.

The magnitude of change in the fetal cerebroplacental ratio in the third trimester and the risk of adverse pregnancy outcome. Ultrasound Obstet Gynecol. 2016 Nov 22;: Authors: Flatley C, Greer RM, Kumar S Abstract OBJECTIVE: The primary aim of this study was to evaluate if the magnitude of change in the cerebro-placental ratio (CPR) after 30 weeks gestation was better predictive of adverse pregnancy outcome compared to a single measurement at 35-37 weeks. A secondary aim was to evaluate whether the utility of CPR measured at 35-37 weeks was enhanced after adjusting for the gestational change. METHODS: This was a retrospective cohort study of women who had had at least two ultrasound scans between 30-37 weeks gestation with the final scan taking place at 35-37 weeks. Exclusion criteria included major congenital abnormality, aneuploidy, multiple pregnancy and unknown middle cerebral artery pulsatility index (MCA PI) or umbilical artery pulsatility index (UA PI). A normal reference cohort for the CPR was derived from a separate cohort of women with normal outcomes and a Generalised Additive Model for Location, Scale and Shape (GAMLSS) model fitted to derive standardised centiles. These reference centiles were then used to calculate z-scores for the study cohort. Logistic regression models and Receiver Operating Characteristic (ROC) curves were used to evaluate the predictive utility of the CPR z-score at the last CPR measurement and the change in CPR, ...
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research

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Bianca Cox1†, Maria Tsamou1†, Karen Vrijens1, Kristof Y. Neven1, Ellen Winckelmans1, Theo M. de Kok2, Michelle Plusquin1 and Tim S. Nawrot1,3* 1Center for Environmental Sciences, Hasselt University, Hasselt, Belgium 2Department of Toxicogenomics, Maastricht University, Maastricht, Netherlands 3Department of Public Health, Environment and Health Unit, Leuven University (KU Leuven), Leuven, Belgium Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and later-life health of the newborn, yet the implicated molecular mechanisms remain largely unknown. As the master reg...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study aimed to compare the effect of high-intensity interval training (HIIT) with moderate-intensity continuous training (MCT) on endothelial function, oxidative stress and clinical fitness in patients with type 1 diabetes. Thirty-six type 1 diabetic patients (mean age 23.5 ± 6 years) were randomized into 3 groups: HIIT, MCT, and a non-exercising group (CON). Exercise was performed in a stationary cycle ergometers during 40 min, 3 times/week, for 8 weeks at 50–85% maximal heart rate (HRmax) in HIIT and 50% HRmax in MCT. Endothelial function was measured by flow-mediated dilation (FMD) [endothelium-depende...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Discussion Intrauterine growth retardation or fetal growth retardation is due to a pathological process that causes decelerated fetal growth velocity. Small-for-gestational age (SGA) is an infant with growth parameters below the normal range for gestational age. More commonly, SGA is defined as a birth weight
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSION: Pregnant women with NAFLD have increased risk for GDM, pre-eclampsia, hypertension, hyperuricemia, increasing total cholesterol and triglycerides and should be carefully monitored during antenatal care.b. PMID: 29943682 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
Authors: Berceanu C, Tetileanu AV, Ofiţeru AM, Brătilă E, Mehedinţu C, Voicu NL, Szasz FA, Berceanu S, Vlădăreanu S, Navolan DB Abstract The purpose of this study is to analyze the morphological, histological, immunohistochemical and ultrasound findings in the placenta of maternal type 1 and gestational diabetes, to compare the pathological changes of the placental structure in the two types of metabolic disruptions, but also to establish correlations with the expression of these findings, influenced by different associated conditions. This multicenter study includes 53 pregnancies, of which 37 with pregestat...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
ABSTRACT ObjectivesTo evaluate whether the magnitude of change in the cerebroplacental ratio (CPR) after 30 weeks' gestation is a better predictor of adverse pregnancy outcome compared with a single CPR measurement at 35–37 weeks. A secondary aim was to evaluate whether the utility of CPR at 35–37 weeks was enhanced after adjusting for change in gestational age. MethodsThis was a retrospective cohort study of women who had at least two ultrasound scans between 30 and 37 weeks' gestation, with the final scan at 35–37 weeks. Exclusion criteria were major congenital abnorma...
Source: Ultrasound in Obstetrics and Gynecology - Category: Radiology Authors: Tags: Original Paper Source Type: research
ConclusionsIn a low‐risk population, ultrasound‐estimated accelerated fetal growth in early pregnancy was associated with an increased risk of having a severely LGA or macrosomic infant.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
ConclusionsIn a low‐risk population, ultrasound‐estimated accelerated fetal growth in early pregnancy was associated with an increased risk of having a severely LGA or macrosomic infant.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Original Research Article Source Type: research
Conclusion: Abdominal ultrasound examination in this population has a low clinical yield. The decision to perform an abdominal ultrasound must be individualized based on the obstetric history, clinical findings, and the level of liver enzymes.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
Abstract ObjectiveThe primary aim of this study was to evaluate if the magnitude of change in the cerebro‐placental ratio (CPR) after 30 weeks gestation was better predictive of adverse pregnancy outcome compared to a single measurement at 35‐37 weeks. A secondary aim was to evaluate whether the utility of CPR measured at 35‐37 weeks was enhanced after adjusting for the gestational change. MethodsThis was a retrospective cohort study of women who had had at least two ultrasound scans between 30‐37 weeks gestation with the final scan taking place at 35‐37 weeks. Exclusion criteria included major congenital abnorma...
Source: Ultrasound in Obstetrics and Gynecology - Category: Radiology Authors: Tags: Original Paper Source Type: research
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