Human parechovirus and enterovirus initiate distinct CNS innate immune responses: pathogenic and diagnostic implications

Meningitis is one of the most common central nervous system (CNS) disorders of childhood, and when considering all etiologies of meningitis, this disease is responsible for up to 12% of deaths worldwide in children younger than 14 years of age [1,2]. The majority of the aseptic cases of meningitis are viral infections with most caused by non-polio enteroviruses (EV) and human parechoviruses (HPeV) [3]. EV and HPeV are both members of the family Picornaviridae, which are small non-enveloped, positive sense, single stranded RNA viruses [4].

Source: Journal of Clinical Virology - November 22, 2016 Category: Virology Authors: Danielle Fortuna, Ana Mar ía Cárdenas, Erin H. Graf, Larry A. Harshyne, D.Craig Hooper, Michael Prosniak, John Shields, Mark T. Curtis Source Type: research