Washington University and Harvard Medical School report positive topical immunotherapy trial results

The Washington University School of Medicine in St. Louis and Harvard Medical School have reported positive results from a clinical study of combination of two topical drugs, cream formulation of topical 5-fluorouracil and calcipotriol, to treat earl …
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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We describe the principles of imaging host T-cells and adoptively transferred therapeutic T-cells as well as the value of traceable cancer cell models in immunotherapy development. Our emphasis is on in vivo cell tracking methodology, including important aspects and caveats specific to immunotherapies. We discuss a variety of associated experimental design aspects including parameters such as cell type, observation times and intervals, and detection sensitivity. The focus is on preclinical cell tracking but aspects relevant for clinical translation are also discussed.
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 2 April 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Yuliya Afinogenova, Tamar Rubin, Sagar Patel, Rachel Powell, Janina Gilo, Morgan Denno, Gary Soffer, Jason Lee, Louis Mendelson, Jeffrey Factor
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Contributors : Dawn S Lin ; Luyi Tian ; Daniela Amann-Zalcenstein ; Tracey M Baldwin ; Shalin H NaikSeries Type : Expression profiling by high throughput sequencingOrganism :Flt3 ligand (Flt3L) promotes an increased generation of type 1 conventional dendritic cells (cDC1s), resulting in enhanced immunity against infections and cancer. Here, we employ cellular barcoding to understand how Flt3L regulates single haematopoietic stem and progenitor cell (HSPC) fate. Our results demonstrate that although Flt3L stimulation can recruit some additional cDC1-generating HSPCs, the major contributing factor to higher cDC1 numbers is t...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Cancer immunotherapy has reached a critical point, now that immune checkpoint inhibitors and two CAR-T products have received market approval in treating 16 types of cancers and 1 tissue-agnostic cancer indica...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Review Source Type: research
Immunotherapy with immune checkpoint inhibitors (ICIs) for solid tumors had significantly improved overall survival. This type of therapy is still not available for acute myeloid leukemia (AML). One major issu...
Source: Journal of Hematology and Oncology - Category: Hematology Authors: Tags: Letter to the Editor Source Type: research
ConclusionThis work indicated the ability of LcZ to alleviate TM ‐induced food allergy and demonstrated the involvement of the tolerogenic immune cells and NF‐κB signaling pathway, indicating LcZ to be a potential immunomodulator and immunotherapy assistor.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
AbstractOn-treatment steroids for countering immune checkpoint inhibitor-induced inflammatory responses (irAEs) are a hallmark of cancer immunotherapy. However, the suppressive nature of steroids has raised questions regarding their ability to compromise the function of the ‘proliferative burst’ of effector T cells induced by immune checkpoint antibodies. We investigated the effector functions and the co-inhibitory receptor profile of stimulated peripheral blood mononuclear cells (PBMCs) pre-treated with prednisone and dexamethasone alone or in the presence of anti -PD-1/CTLA-4 antibodies. Also, clinical analys...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
ConclusionsThis novel approach starting from routine diagnostics in a dedicated laboratory provides reliable and useful results with therapeutic implications. Counseling should consider clinical presentation, demographic features, and antibody titers of the individual patient.
Source: Journal of Neurology - Category: Neurology Source Type: research
ConclusionOur present data show anti-tumor effects mediated by dinutuximab beta against GBM cells providing a rationale for a GD2-directed immunotherapy against GBM. Due to high CRP expression, a combining of GD2-targeting with CRP blockade might be a further treatment option for GBM.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of ReviewDiscuss optimal conditions for the office delivery of allergy immunotherapy with regard to medical personnel supervision and techniques for sterility of antigen vial preparation and delivery.Recent FindingsThe revised USP 797 pharmaceutical compounding guidelines, combined with allergen extract preparation directions provide clear instructions for the general supervision and oversight of allergen preparation for immunotherapy.SummarySterility of antigen vial preparation and supervision of office personnel delivering and preparing allergy immunotherapy are critical points of competency allowing for ...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
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