Men have a lot to learn about their own fertility

(McGill University) The first large-scale study of its kind has revealed that Canadian men generally lack knowledge about the risk factors contributing to male infertility. Research led by Dr. Phyllis Zelkowitz, head of psychosocial research at the Lady Davis Institute of the Jewish General Hospital, found that men could only identify about 50% of the potential risks and medical conditions that are detrimental to their sperm count and, thus, their prospects to father children.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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This study aimed to clarify functions of uterine HIF using transgenic mouse models. Mice with deletion of Hif2a in the whole uterus (Hif2a-uKO mice) showed infertility due to implantation failure. Supplementation with progesterone (P4) and leukemia inhibitory factor (LIF) restored decidual growth arrest and aberrant position of implantation sites in Hif2a-uKO mice, respectively, but did not rescue pregnancy failure. Histological analyses in Hif2a-uKO mice revealed persistence of the intact luminal epithelium, which blocked direct contact between stroma and embryo, inactivation of PI3K-AKT pathway (embryonic survival signal...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
By Michelle Catenacci, M.DCHICAGO, Jun 18 2018 (IPS)Fertility health is an incredibly personal – and often vulnerable – topic. Fertility, infertility, and fertility preservation have gained increased public interest over the past few years. Infertility is formally defined as the inability to achieve pregnancy after one year of unprotected intercourse. The Centers for Disease Control and Prevention (CDC) reports that approximately 12% of women aged 15 to 44 in the United States have difficulty getting pregnant or carrying a pregnancy to term. Even though a significant proportion of the population suffers from th...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Education Featured Gender Global Headlines Health Population Poverty & SDGs TerraViva United Nations Source Type: news
ConclusionsThe lack of association of the evaluated genes in this sample of Mexican women is consistent with the complex genetic etiology of POI that is observed across cohorts studied thus far.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
Authors: Xie D, Lu C, Zhu Y, Zhu S, Yang EJ, Jin X Abstract We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement cont...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
AbstractPurpose of ReviewMale pattern hair loss, mediated by dihydrotestosterone, is a common hair loss disorder, affecting over 50% of men over the age of 50. The 5- α reductase inhibitors, finasteride and dutasteride, are Food and Drug Administration-approved drugs for the treatment of this disorder. Several recent studies have reported adverse sexual and spermatogenic events among young men using 5-α reductase inhibitors, such as erectile dysfunction, decrea sed ejaculate volume, decreased libido, and infertility. In this review, we summarize and analyze the literature regarding the efficacy and safety of th...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
In conclusion, the results of the present study identified several mRNAs involved in sperm morphological development, which may aid in the understanding and treatment of infertility. PMID: 29901159 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Inflammatory cytokine profile of co‑cultivated primary cells from the endometrium of women with and without endometriosis. Mol Med Rep. 2018 Jun 06;: Authors: Luckow Invitti A, Schor E, Martins Parreira R, Kopelman A, Kamergorodsky G, Gonçalves GA, Batista Castello Girão MJ Abstract Endometriosis is a chronic gynecological disorder defined as the presence of endometrial tissue within extra-uterine sites. The primary symptoms are infertility and chronic pain. The inflammatory environment and aberrant immune responses in women with endometriosis may be directly associated with the initiat...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Conditions:   Implantation Failure;   Infertility, Female Interventions:   Other: FET according to ERA;   Other: FET according to standard protocol Sponsors:   Shady Grove Fertility Reproductive Science Center;   Igenomix Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we used CRISPR to construct an NPC1-/- zebrafish model, which faithfully reproduced the cardinal pathological features of this disease. In contrast to the wild type, the deletion of NPC1 alone caused significant hepatosplenomegaly, ataxia, Purkinje cell death, increased lipid storage, infertility and reduced body length and life span. Most of the NPC1-/- zebrafish died within the first month post fertilization, while the remaining specimens developed slower than the wild type and died before reaching eight months of age. Filipin-stained hepatocytes of the NPC1-/- zebrafish were clear, indicating abnormal acc...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Conclusions This study demonstrates that the use of ICSI for unexplained infertility achieved similar reproductive outcomes as male infertility cases, which are usually referred to ICSI. It also shows that the quality of semen did not positively affect ICSI outcomes.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
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