NIAID-supported scientists sequence, explore the genome of the river blindness parasite

(NIH/National Institute of Allergy and Infectious Diseases) Scientists have sequenced the genome of the parasitic worm responsible for causing onchocerciasis -- an eye and skin infection more commonly known as river blindness. Through their work, researchers have gained insight into the workings of the parasite and identified proteins that potentially could be targeted with existing drugs or provide areas for developing new treatments and a preventive vaccine. The NIAID-supported research is described in a pair of papers published this week in Nature Microbiology.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Authors: Insamran W, Sangrajrang S Abstract Since 2000 cancer has been the leading cause of death in Thailand. In response to this challenge, the National Cancer Institute of Thailand (NCI), in collaboration with other bodies, has developed and promoted the National Cancer Control Program (NCCP) to provide appropriate policies and practice for the prevention, early detection and treatment of cancer, with optimal supportive care. With plans strongly supported by the Ministry of Public Health, the NCCP envisages integration into the health care system in 6 strategic areas: (1) cancer informatics; (2) primary preventi...
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
No abstract available
Source: RETINA - Category: Opthalmology Tags: Editorial Source Type: research
To prepare for annual flu seasons, as well as possible pandemics, the US government has invested tens -- if not hundreds -- of millions of dollars over the past 15 years to ensure there are enough eggs for vaccines.
Source: - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 26 March 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Marcus S. Shaker, John Oppenheimer, Mitchell Grayson, David Stukus, Nicholas Hartog, Elena W.Y. Hsieh, Nicholas Rider, Cullen M. Dutmer, Timothy K. Vander Leek, Harold Kim, Edmond S. Chan, Doug Mack, Anne K. Ellis, David Lang, Jay Lieberman, David Fleischer, David B.K. Golden, Dana Wallace, Jay Portnoy, Giselle Mosnaim
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
BackgroundTemporary disruption of sensory input can be studied relatively easily for vision or hearing by covering the eyes or ears. In contrast, closing the nostrils affects not only the sense of smell, but also the ability to breathe through the nose and humidify and warm inhaled air. We hypothesized that filling the olfactory cleft (OC) with dissolvable nasal dressing (foam) would temporarily block olfaction while respecting nasal airflow.MethodsIn 30 healthy volunteers, the OC was unilaterally obstructed in a back ‐to‐front fashion. Orthonasal and retronasal olfactory function were tested before and after foam appl...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsSkin exposure to peanut did not lead to sensitization in this study, and monkeys did not experience anaphylaxis upon peanut challenge. However, monkeys produced increased peanut ‐specific IgG throughout peanut exposure, indicating that repeated skin exposure to peanut is immunogenic.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This study investigated the effects of human umbilical-cord mesenchymal stem cells (HUMSCs) injection on diabetic rat model. The results show that the level of MIAT is significantly decreased in the diabetic retina after the injection of HUMSCs. Moreover, HUMSCs can significantly decrease the expression of IL-1β and IL-6 mRNA; alleviate microvascular permeability, and upregulate Occludin expression. Studies have shown that MIAT knockdown could alleviate diabetes-induced inflammation responses and vascular leakage. Furthermore, our findings also showed that the expression of MIAT was positively correlated with the expr...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
The oral immunomodulator is indicated for treatment of adults with relapsing remitting multiple sclerosis (RRMS) with active disease as defined by clinical or imaging features.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Alert Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) River blindness, or onchocerciasis, is a disease caused by a parasitic worm (Onchocerca volvulus) found primarily in Africa. Ivermectin is used to treat onchocerciasis. This treatment can be fatal when a person has high blood levels of another worm, Loa loa. In a paper published in NEJM, scientists describe how a cell phone-based videomicroscope can provide fast, effective testing for L. loa parasites, allowing these individuals to be protected from the adverse effects of ivermectin.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Conclusion This study suggests a new smartphone-based approach could provide a quick way of measuring levels of infection with the Loa loa worm in blood samples, and with a high level of accuracy. This technique could allow assessment of people's infection in communities without easy access to the laboratory testing that is usually used to detect the worms. This is important, as people with high levels of this infection can suffer potentially fatal side effects with the drug ivermectin, which is used to treat two other parasitic infections. It's worth bearing in mind that this was a pilot study in only 33 people using a ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Source Type: news
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