Severe changes in colon epithelium in the Mecp2 -null mouse model of Rett syndrome

ConclusionsIn summary, we showed that the colon is severely affected by Mecp2 silencing in mice. Changes in colon length and epithelial histology are similar to those observed in colitis. Changes in the localization of proteins that participate in fluid absorption can explain watery stools, but the exclusive deletion of Mecp2 from the intestine did not reproduce colon changes observed in theMecp2-null mice, indicating the participation of other cells in this phenotype and the complex interaction between different cell types in this disease.
Source: Molecular and Cellular Pediatrics - Category: Cytology Source Type: research