99mTc-labeled white blood cell scan as a guide to open biopsy in the management of hip and knee prosthesis infection: Preliminary results.

99mTc-labeled white blood cell scan as a guide to open biopsy in the management of hip and knee prosthesis infection: Preliminary results. Curr Radiopharm. 2016 Nov 17; Authors: Liberatore M, Gentile G, Follacchio GA, Frantellizzi V, De Vincentis G, Monteleone F, Anagnostou C, Drudi FM, Calvisi V Abstract The aim of the present prospective study was to evaluate the usefulness of labeled leukocyte scan as a guide to open biopsy for the management of hip and knee prosthesis infection in patients without loosening of orthopedic device. Twenty-six patients with suspected hip (24) and knee (2) prosthesis infection underwent routine analysis of blood, plain radiography and 99m Tc-HMPAO labelled leukocyte scan (WBCS). On these basis, patients were subdivided in the following groups: bone infection without loosening (n°=14), septic loosening (n°=8), superficial infection (n°=2), no infection (n°=2). Patients with septic loosening underwent empirical antibiotic therapy in order to avoid two-stage re-implantation. When the medical treatment was effective patients were submitted to one-stage operation. Patients without loosening of prosthesis but positive WBCS results underwent open biopsy: bone samples and periprosthetic tissues were taken from the regions showing pathological leukocyte uptake at the scan. Samples were submitted to microbiological examination and antibiotic treatments were undertaken in cases of bacterial growth. A 24-mont...
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research