The Efficacy of Platelet-Derived Growth Factor as a Bone-Stimulating Agent

This article highlights findings from basic science, animal, and human clinical research that led to the approval of Augment Bone Graft. We present an adaptation of the surgical techniques described for investigators participating in the pivotal trial.
Source: Foot and Ankle Clinics - Category: Orthopaedics Authors: Source Type: research

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Anterior cruciate ligament (ACL) rupture is one of the most common types of knee joint sports injury. Patients with a rupture of the ACL may lead to swelling, pain, instability, mechanical dysfunction, and non-surgical treatment will also increase the risk of further meniscus injury and degenerative joint disease [1,2]. The most frequently used auto-grafts for ACL reconstruction (ACLR) are bone-patellar tendon-bone (BPTB) and four-strand hamstring tendon (4S-HT), but significant controversy exists about which graft is better.
Source: Injury - Category: Orthopaedics Authors: Source Type: research
Abstract BACKGROUND: The Bernese periacetabular osteotomy (PAO) is one of the most-used surgical techniques to treat symptomatic acetabular dysplasia. Although good functional and radiographic short-term and long-term outcomes have been reported, several complications after PAO have been described. One complication that may compromise clinical results is nonunion of an osteotomy. However, the exact prevalence and risk factors associated with nonunion are poorly elucidated. QUESTIONS/PURPOSES: (1) What proportion of patients have complete bony healing versus nonunion during the first year after PAO? (2) What i...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
(Tohoku University) A new recipe for a bone-graft biomaterial that is supercooled before application should make it easier to meet dental patients' expectation of a good-looking smile while eliminating the pain associated with harvesting bone from elsewhere in their body.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Authors: Hunnicutt JL, Slone HS, Xerogeanes JW Abstract The quadriceps tendon (QT) has become increasingly used by orthopaedic surgeons as an alternative autograft choice in anterior cruciate ligament reconstruction. As its use increases, athletic trainers and other rehabilitation clinicians will treat a greater number of patients with this autograft type. The recently developed, minimally invasive technique for harvest of the all-soft tissue autograft has many benefits, including versatility, decreased donor-site morbidity, and enhanced cosmesis. Early clinical trials revealed that the QT autograft resulted in dec...
Source: Journal of Athletic Training - Category: Sports Medicine Tags: J Athl Train Source Type: research
ConclusionPatellar tendon reconstruction with allogeneic tissue from the proximal tibia allograft sutured to the recipient ’s remnant patellar tendon provides the mechanical support needed for healing of the reconstructed extensor mechanism with a substantial functional benefit to stabilize active knee extension and successful reconstruction survival at long-term.Level of evidenceIII.
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
CONCLUSIONS Our study confirmed that by the minimally invasive technique of bone graft harvesting adequate amount of tissue to treat defect fractures and non-unions can be harvested. Spongioplasty using grafts harvested in this manner is effective, with a minimum percentage of non-unions. The advantage of this technique is the proximity of the harvest site and the operative field and low level of pain. The minimally invasive graft harvesting represents a technique with a low risk of postoperative and late complications. Key words: bone graft, autografts, minimally invasive surgery, ilium, pain. PMID: 32396511 [PubMed -...
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research
CONCLUSIONS: To our knowledge, this is the largest case series of surgically managed PAO nonunion. Pelvic instability resulting from nonunion and stress fracture can be satisfactorily addressed by mobilising, grafting and plating the nonunion at the superior pubic ramus. The modified Stoppa approach is suitable in most cases, allowing excellent exposure whilst minimising the insult to soft tissues. The altered anatomy of the pelvis following PAO should be anticipated to reduce the risk to nearby neurovascular structures. PMID: 32390565 [PubMed - as supplied by publisher]
Source: Hip International - Category: Orthopaedics Authors: Tags: Hip Int Source Type: research
J Knee Surg DOI: 10.1055/s-0040-1710361Effective treatment for bipolar articular cartilage lesions in the knee remains a clinical challenge. Lower extremity malalignment is a risk factor for treatment failures, which can be addressed by tibial or femoral osteotomy. The purpose of this study was to compare outcomes among patients who underwent knee joint restoration by osteochondral allograft (OCA) transplantation with concurrent or staged realignment osteotomy. With Institutional Review Board approval, patients undergoing bipolar OCA transplantation with concurrent or staged distal femoral osteotomy (DFO) or high tibial os...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
Chondroblastoma is a rare, benign, cartilaginous-derived tumor accounting for ∼1% to 2% of all primary bone tumors and almost 9% of all benign bone tumors. In this case report, we describe a patient with chondroblastoma and a secondary aneurysmal bone cyst, with the adjacent talus being mildly affected. The initial diagnosis was giant cell tumor and was then confirmed after computed tomography–assisted biopsy. We performed a total calcanectomy via bilateral structural iliac bone autografting to relieve pain and reconstruct the loadbearing function because of the presence of extensive lesions.
Source: Journal of Foot and Ankle Surgery - Category: Orthopaedics Authors: Source Type: research
Conclusions: The results of the present study suggest that PRP can be used to treat a variety of musculoskeletal conditions commonly diagnosed at an academic orthopaedic-specific hospital, with expectations for 78% of patients reporting improvement and an overall patient satisfaction level of 68%. Level of Evidence: Level IV.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
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