Vancouver Experience of Recombinant Human Platelet-Derived Growth Factor

Joint arthrodesis utilizing autogenous bone graft remains the gold standard of treatment in fusion procedures of the foot and ankle. Graft harvest, however, has been associated with increased morbidity to patients as well as increased costs. With this in mind, multiple clinical studies have evaluated the efficacy of recombinant human platelet-derived growth factor (rh-PDGF-BB) with beta-tricalcium phosphate (B-TCP) to augment in foot and ankle arthrodesis with favorable results. These factors have led to the increased use of rh-PDGF-BB with B-TCP in Vancouver with good clinical results.
Source: Foot and Ankle Clinics - Category: Orthopaedics Authors: Source Type: research

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Publication date: September 2020Source: Urology Case Reports, Volume 32Author(s): Gilbert Pan, Faris Ahmed, Jeffrey Campsen
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conditions:   Wrist Arthritis;   Fusion; Joint Interventions:   Procedure: PRC;   Procedure: AO Sponsors:   Töölö Hospital;   Turku University Hospital;   Kymenlaakso Central Hospital Kotka Finland Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Stress shielding and bone loss of the femur are of great concern after revision total hip arthroplasty (THA) with extensively porous-coated stems, especially in a femur with already bone loss. The femoral bone...
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Tags: Research article Source Type: research
The direct association of obesity with overall health is incontrovertible, including an association with increased cardiovascular disease and higher mortality rates. The health outcomes of obesity are further exacerbated in patients with end-stage kidney disease (ESKD), and compounding this problem, the one intervention that can dramatically improve life span, kidney transplant, is often not offered to these patients. Lassalle et al showed that patients with a body mass index (calculated as weight in kilograms divided by height in meters squared) of 31 or more were less likely to receive a kidney transplant, and inversely,...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
CONCLUSION: Appropriate monitoring of graft function is necessary in patients with cured PTCs. PMID: 32449324 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Abstract Background and purpose - Early postoperative implant migration predicts failure of joint replacements. Bone mineral density reflects bone quality and bone-graft incorporation. Implant migration and bone densitometry analysis usually require special equipment. We investigated cup migration and bone mineral density changes simultaneously with low-dose CT scans after acetabular revision hip arthroplasty using impaction bone grafting.Patients and methods - We performed a low-dose CT postoperatively, after 6 weeks, and after 2 years in 17 patients, all revised using impaction bone grafting and a graft-compress...
Source: Acta Orthopaedica - Category: Orthopaedics Authors: Tags: Acta Orthop Source Type: research
Conclusion: Combining PRGF and ADSCs boosts the bone graft regenerative potential at the earliest period of healing. PMID: 32452715 [PubMed - as supplied by publisher]
Source: Regenerative Medicine - Category: Genetics & Stem Cells Authors: Tags: Regen Med Source Type: research
This study addresses the in vitrobiologic effects of a clinically available dehydrated amniotic membrane allograft (DAMA). The broad mechanism of action results from DAMA's biologic composition that leads to stimulation of cell migration cell proliferation, and reduction of pro ‐inflammatory cytokines. Results show that DAMA possesses growth factors and cytokines such as EGF, FGF, PDGFs, VEGF, TGF‐β, IL‐8, and TIMPs 1 and 2. Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the re duction of pro‐inflammatory cytokines IL‐1...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: ORIGINAL RESEARCH REPORT Source Type: research
Condition:   the Efficacy and Effect on Patient Comfort of a Hidden-knot Continuous Suture for Pterygium Excision With Conjunctival Autograft Intervention:   Procedure: suture Sponsor:   Aier School of Ophthalmology, Central South University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractMicrovascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) is identified as an independent risk factor for poor prognosis in patients with acute myocardial infarction (AMI). The inflammatory response induced by ischemia and reperfusion (I/R) injury is considered one of the main mechanisms of MVO. Mesenchymal stem cells (MSCs) are a unique stromal cell type that confers an immunomodulatory effect in cardiac disease. The present study aimed to investigate whether immediate intravenous delivery of MSCs could be used as a potential therapeutic method to attenuate MVO formation. A cardiac ca...
Source: Basic Research in Cardiology - Category: Cardiology Source Type: research
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