Incidence and temporal trends of type 1 diabetes in China: a systematic review and meta-analysis

This study is registered with PROSPERO, number CRD42016039284. Findings We identified 816 reports from the search and included 19 reports of population-based studies published between 1994 and 2015 in the analysis. Overall incidence of type 1 diabetes in mainland China was 0·74 (95% CI 0·55–1·00) per 100 000 person-years between 1980 and 2013. Incidence (per 100 000 person-years) increased rapidly from 0·57 (0·43–0·75) in 1990 to 1·04 (0·64–1·68) in 2000 and 3·36 (1·66–6·82) in 2010 (p<0·0001). The mean annual increase in incidence was 9·0% (5·1–15·9), and the increase was numerically higher in boys (10·6%, 95% CI 4·7–23·6) than in girls (7·2%, 2·7–18·8). Incidence was significantly higher in girls than in boys (IRR 1·23, 95% CI 1·12–1·36; p<0·0001), and this disparity was most profound in children aged 5–9 years (1·71, 1·27–2·29; p=0·00036). However, no obvious difference in incidence between boys and girls was seen in children aged 0–4 years (0·91, 0·70–1·18; p=0·46) and in those aged 10–14 years (1·09, 0·97–1·24; p=0·16). Using the age group of 0–4 years as reference, IRR increased from 2·21 (1·81–2·70; p<0·0001) for children aged 5–9 years to 2·99 (2·25–3·99; p<0·0001) for children aged 10–14 years. The IRR for urban versus rural areas was 1·82 (1·37–2·41; p=0·0001). Interpretation To our knowledge, this is the first systematic review and meta-analys...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research