Effects of aerobic exercise and diet intervention on glycaemic control and liver fat content in men and women aged 50 –65 years with prediabetes and non-alcoholic fatty liver disease: a multicentre, randomised controlled trial

Publication date: November 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Supplement 1 Author(s): Sulin Cheng, Jun Ge, Can Zhao, Petri Wiklund, Shenglong Le, Yifan Yang, Dandan Ke, Na Wu, Xiao Tan, Jianqin Sun, Renwei Wang, Yongyong Shi, Ronald Borra, Riitta Parkkola, Dajiang Lu Background Prediabetes and non-alcoholic fatty liver disease precede development of type 2 diabetes; however, appropriate lifestyle interventions might help to prevent such progression. We aimed to test whether aerobic exercise training and a high-fibre diet can reduce hepatic fat content and increase insulin sensitivity in individuals with prediabetes and non-alcoholic fatty liver disease. Methods We did a randomised controlled trial in seven clinics in Yangpu district, Shanghai, China. We recruited individuals aged 50–65 years with impaired fasting glucose (5·6–6·9 mmol/L) or impaired glucose tolerance (2 h glucose 7·8–11·0 mmol/L) and diagnosed non-alcoholic fatty liver disease. We randomly assigned (1:1:1:1) participants to receive aerobic exercise, diet intervention, aerobic exercise plus diet intervention, or no intervention (control group) for 8 months. A computer program was used to generate the block randomisation sequence (block size 20). Progressive aerobic exercise training (60–75% intensity) was given three to five times per week in 30–60 min sessions. The diet intervention aimed to include 40% carbohydrate with a fibre intake of 18–25...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research