< b > < i > Wilms Tumor 1 < /i > < /b > < b > ( < /b > < b > < i > WT1 < /i > < /b > < b > ) < /b > mRNA Expression Level at Diagnosis Is a Significant Prognostic Marker in Elderly Patients with Myelodysplastic Syndrome

Background/Aims: A high expression ofWilms tumor 1(WT1) mRNA occurs in most cases of acute leukemia and myelodysplastic syndrome (MDS). Although there are many reports suggesting that acute myeloid leukemia patients with high expression levels ofWT1 mRNA have a relatively poor long-term survival, there are few reports addressing the relationship between WT1 levels and prognosis in MDS.Methods: We retrospectively analyzed 42 elderly patients with MDS whoseWT1levels at diagnosis were available, and we assessed the relationships betweenWT1levels in peripheral blood and preexisting prognostic factors such as World Health Organization prognostic scores and Revised International Prognostic Scoring System risk categories, bone marrow blast percentages, and chromosomal abnormalities linked to a poor prognosis. We also evaluated the relationship between WT1levels and prognosis.Results:WT1levels were significantly different between high- and low-risk MDS patients (p
Source: Acta Haematologica - Category: Hematology Source Type: research