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Challenge of neuroborreliosis.

[Challenge of neuroborreliosis]. Nervenarzt. 2016 Nov 15; Authors: Spreer A, Rauer S, Wilking H, Fingerle V Abstract Lyme borreliosis is the most frequent tick-borne infection in Europe. It is a multisystemic disease affecting the skin, joints, heart, in rare cases the eyes and regularly the nervous system. Taking current clinical and microbiological guidelines into account, neuroborreliosis can in general be diagnosed and treated successfully. An appropriate guideline-conform antibiotic treatment is effective and in most cases recovery from acute neuroborreliosis is complete. Nevertheless, the evidence base regarding pharmacological treatment needs reform and improvement. Contrary to this scientifically based medical opinion, divergent opinions presented in the media cause uncertainty and confusion among patients and also some physicians. The currently available scientific data on epidemiology, treatment and performance of microbiological testing reveals gaps and therefore a large scope for interpretation. In clinical practice, diagnostics and therapeutic methods that do not fulfill the criteria of evidence-based medicine are widely used due to the uncertain data situation. The Clinical Network Neuroborreliosis (KNN) is a publicly funded network of clinicians and clinical laboratory physicians with the goal to improve knowledge for disease-oriented evaluation of diagnostic and therapeutic methods. In addition, the Robert Koch Institute (RKI) and th...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research

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Authors: Paparone PW Abstract Preview The presentation of Lyme disease may resemble that of polymyalgia rheumatica. What's more, the latter may occur in patients who have positive serologic findings for the former. In this case report, the author describes differential diagnosis in an elderly patient whose rheumatic complaints and blood chemistry profile alone could easily have led to misdiagnosis. Important points in evaluation and treatment are discussed. PMID: 29219773 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Authors: Masters EJ Abstract Preview Because disseminated Lyme disease can be devastating, early recognition and treatment are important. The presence of erythema migrans offers the best opportunity for early diagnosis. Therefore, public awareness and patient education about the rash of Lyme disease are critical. Dr Masters gives practical pointers from his own experience in evaluation of erythema migrans and reviews current treatment recommendations. PMID: 29219679 [PubMed]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
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Source: Physician's First Watch current issue - Category: Primary Care Source Type: news
(Rutgers University) New diagnostic methods offer a better chance for more accurate detection of the infection from the Lyme bacteria, the most common tick-borne infection in North America and Europe.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The objective of the present study was to examine the interaction of skin fibroblasts withB. burgdorferi sensu stricto B31 (BB) andB. afzelii (BA) in vitro by electron microscopy. We also determined the expression of collagen type I, TGF- β, FGF-1, calreticulin (CALR), decorin (DCN), and PDGF-α at the mRNA level inBorrelia/fibroblast co-cultures. IntactBorrelia attach to and transmigrate fibroblasts, and undergo cystic transformation outside the fibroblasts. Fibroblasts preserve their vitality and express a prominent granular endoplasmic reticulum, suggesting activated protein synthesis. On two different semi-qu...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
Publication date: Available online 6 December 2017 Source:Ticks and Tick-borne Diseases Author(s): Nanna Skaarup Andersen, Sigurdur Skarphédinsson, Fredrikke C Knudtzen, Carsten Riis Olesen, Thøger Gorm Jensen, Per Moestrup Jensen Lyme neuroborreliosis is the most severe clinical manifestation of Lyme borreliosis. In most of Denmark, and also Europe, the overall prevalence of Lyme borreliosis seems to be stabilising. This is not the case on the island of Funen, Denmark, where the number of human Lyme neuroborreliosis cases has markedly declined throughout the last decade. We propose the reason for the declin...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
As several studies indicated an increase in Lyme disease (LD), notably in neighbouring countries, concerns have arisen regarding the evolution of Lyme disease in Belgium. In order to confirm or infirm the incr...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Lyme borreliosis (LB) is the most common reported tick-borne infection in Europe, and involves transmission of Borrelia by ticks. As long as a vaccine is not available and effective measures for controlling tick ...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
​BY ANUMEHA SINGH, MD, &ANDREJ KIELTYKA, PASymptomatic bradycardia is usually reserved for the over-the-hill crowd, but it is not entirely unheard of in the young and healthy. A 21-year-old African American man was sent to the emergency department by his primary care provider. The patient had no previous medical issues, normal vital signs, and was fine until about a week prior. He had quickly worsening shortness of breath while climbing the stairs to get to his dorm bedroom. The young man denied having been out in the woods or noting tick bites. He had no family history of cardiomyopathy or early cardiac events.​Th...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Immune System Bell's Palsy Herpes Viruses Steroids Lyme Disease Nerves and Nervous System Source Type: news
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