Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N -Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone

ConclusionsClinical DDI potential of specific CYP enzymes needs to be considered arising due to circulatory concentrations of certainN-oxides depending on the dose size and/or frequency of dosing of the respective parent drugs.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research