Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma

A constant relative biological effectiveness (RBE) is used for clinical proton therapy; however, experimental evidence indicates that RBE can vary. We analyzed pediatric ependymoma patients who received proton therapy to determine if areas of normal tissue damage indicated by post-treatment image changes were associated with increased biological dose effectiveness.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original article Source Type: research