The relationship between heart rate variability and left ventricular layer-specific deformation in uncomplicated diabetic patients
AbstractThe aim of this study was to investigate heart rate variability (HRV) and left ventricular (LV) remodeling in uncomplicated diabetic patients. Furthermore, we sought to investigate the association between HRV indices and LV structural, functional and mechanical parameters. This cross-sectional study included 50 uncomplicated patients with type 2 diabetes and 40 healthy controls without cardiovascular risk factors. All study subjects underwent 24-h Holter monitoring, laboratory analyses and complete two-dimensional echocardiography examination (2DE). LV structure and diastolic function were significantly deteriorated in the diabetic patients comparing with the controls. LV global longitudinal, circumferential and radial strains were significantly reduced in the diabetic group. LV endocardial, mid-miocardial and epicardial longitudinal and circumferential strains were significantly decreased, whereas LV twist was significantly increased, in the diabetic patients; 24-h, daytime and nighttime heart rates were higher in the diabetic patients. All parameters of time and frequency domain of HRV were reduced in the diabetic subjects. LV mass index, mitral E/e ′ ratio and 2DE LV endocardial and mid-miocardial longitudinal and circumferential strains correlated with HRV parameters. A multivariate regression analysis showed that E/e′ ratio and 2DE LV layer-specific strains were associated with HRV parameters independently of age, BMI, systolic blood pre ssure and LV ...
Publication date: 7 April 2020Source: Cell Reports, Volume 31, Issue 1Author(s): Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
TYPE 2 diabetes is a chronic condition that requires you to take extra care of your health to prevent high blood sugar levels. Diet plays a key role here and evidence suggests there are some items you shouldn't go without, including a particular supplement.
Authors: Choi JB, Yoo JM, Lee YJ, Kim JW, Lee SJ, Kim HY, Lee DS, Ko SH, Choe HS Abstract PURPOSE: To investigate the effect of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on inflammatory cytokines of urogenital tissue in a rat model of type 2 diabetes (T2DM) to infer pharmaceutical influence of dapagliflozin on genitourinary infection or inflammation. METHODS: Study animals were divided into the following 4 groups of 10 animals each: (1) the Otsuka Long-Evans Tokushima Fatty (OLETF)-DA group treated with dapagliflozin at 1.0 mg/kg/day, (2) the OLETF-VO group treated with voglibose at 0.6 mg/kg/d...
We often think of self-development as a pursuit that builds positive capabilities such as courage, ambition, or a success mindset. And of course it can generate many positive results if we truly invest in it, such as loving relationships, a meaningful and lucrative career, and a rewarding lifestyle. But we can easily overlook just how beautifully self-development protects us from major problems in life, including serious but common problems that drag many people down for years, if not decades. Preventing Self-Destruction I originally got into self-development as a path away from self-destructive behavior when I wa...
Publication date: Available online 7 April 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Vahideh Behrouz, Ali Dastkhosh, Golbon Sohrab
Publication date: Available online 9 December 2019Source: Canadian Journal of DiabetesAuthor(s): Lingning Huang, Yongze Zhang, Yunmin Wang, Ximei Shen, Sunjie Yan
(JAMA Network) Metformin is the most commonly prescribed noninsulin medication for type 2 diabetes and this observational study examined postoperative death and hospital readmission among adults with type 2 diabetes who had a prescription for metformin before major surgery with those who didn't.
Publication date: Available online 7 April 2020Source: Academic PediatricsAuthor(s): Marcela Osorio, Christian A. Koziatek, Mary Pat Gallagher, Jessie Recaii, Meryle Weinstein, Lorna E. Thorpe, Brian Elbel, David C. Lee
This cohort study describes the mortality and readmission outcomes of prescribing metformin beyond its use to control blood glucose levels in adults with type 2 diabetes.