Development of Antibody-Based Vaccines Targeting the Tumor Vasculature

A functional vasculature is essential for tumor progression and malignant cell metastasis. Endothelial cells lining blood vessels in the tumor are exposed to a unique microenvironment, which in turn induces expression of specific proteins designated as tumor endothelial markers (TEMs). TEMs either localized at the plasma membrane or secreted into the extracellular matrix are accessible for antibody targeting, which can be either infused or generated de novo via vaccination.
Source: Springer protocols feed by Immunology - Category: Allergy & Immunology Source Type: news