Identifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus Species

Discussion The current outbreak of ZIKV infections has resulted in a massive effort to accelerate the development of ZIKV specific diagnostics and vaccines. These efforts would benefit greatly from the definition of the specific epitope targets of immune responses in ZIKV, but given the relatively recent emergence of ZIKV as a pandemic threat, few such data are available. We used a large body of epitope data for other Flaviviruses that was available from the IEDB for a comparative analysis against the ZIKV proteome in order to project targets of immune responses in ZIKV and their potential properties. The most common approach to diagnose if a person has been infected with ZIKV in the past has been to test by serology if there are antibodies present in the patient’s blood that recognize ZIKV antigens. Several such serological tests exist that probe for the presence of anti-ZIKV antibodies. However, such tests are often unable to distinguish between ZIKV infections and infections with other Flaviviruses, due to the large potential for cross-reactivity27,28,29,30. Our epitope based analysis provides guidance on which components of ZIKV are most likely unique targets of ZIKV specific antibodies (which should be included in a ZIKV specific diagnostic test), and which targets in ZIKV are most likely to be cross-reactive with other Flavivirus species (which should be excluded in a ZIKV specific diagnostic test). In addition to antibody-based tests for ZIKV infection, it is a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

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CONCLUSIONS: Immunohistochemistry seems to be a promising option not only in clinical recognition, but also in the selection and monitoring of treatment effects. However, these methods have not yet recommended for routine clinical use. PMID: 33032462 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
CONCLUSIONS: This single practice study showed total patient contact was similar over both sample periods, but most contact in 2020 was virtual. Further longitudinal multi-practice studies to confirm these findings and describe future consultation patterns are needed to inform general practice service delivery post-COVID-19. PMID: 33032304 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Curious what people think with pandemic and lack of away rotations.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
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Authors: Lam PT PMID: 33034296 [PubMed - as supplied by publisher]
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Source: Neurologia - Category: Neurology Source Type: research
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Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Authors: Jang Y, Kim DW, Yang KI, Byun JI, Seo JG, No YJ, Kang KW, Kim D, Kim KT, Cho YW, Lee ST, Drug Committee of Korean Epilepsy Society Abstract Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of "autoimmune" as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with immunotherapies. Autoimmune epilepsy presents with specific clinical manifestations, and various diagnostic approaches including cerebrospinal fluid analysis, neuroimaging, and autoantibody tests are essential for its differential diagnosis. The diagnosis is o...
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
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