Management of myasthenia gravis compared to national guidelines

Conclusion Management of MG patients at UHB in general comply with national guidelines. However, variations in practice were noted for once or alternate day steroid usage and also regarding reduction or withdrawal of Pyridostigmine.
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Neuromuscular disease, Musculoskeletal syndromes ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

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AbstractSelective immunoglobulin A deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07  g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain thes e phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing systemic...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article is part of a Special Issue entitled: Cholangiocytes in Health and Diseaseedited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Neuromyelitis-optica is a relapsing inflammatory autoimmune condition characterized mainly by acute myelitis and optic neuritis although other criteria exist. IgG against AQP-4 receptor on the astrocyte foot processes is 76% sensitive and 100% Specific for Neuromyelitis-optica. Immunosuppression with Azathioprine is 50% effective but never reported to worsen Neuromyelitis-optica. A 52-year-old-female with history of blindness secondary to bilateral optic neuritis and Myasthenia gravis, in remission, underwent extensive work up for relapsing remitting brain and cervical spine demyelinating lesions and frequent muscle spasms...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Cranial nerves, Infection (neurology), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Spinal cord, Ophthalmology ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research
This study looked into the samples tested during this period to identify any false positive rates. For the purpose of the study, false positive was defined as lack of response to autoimmune myasthenia treatments (and the absence of other clinical or neurophysiological features of MG), or tests requested in error when there was no clinical suspicion of myasthenia. 696 samples were tested for AChR from 582 patients. 280 patients (48.1%) were reported to have positive AChR antibodies. 27 of these were considered to be false positive. We analysed the clinical details of these patients and have identified factors like other aut...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Neuromuscular disease ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research
Abstract Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous system. Myasthenia gravis (MG) is a T cell dependent and antibody mediated autoimmune disease. Although it has been shown that complement plays a critical role in the pathogenesis of MS, GBS, and MG, the role of mannose-binding lectin (MBL) as a biomarker of immunopathogensis of these diseases and also its association with the severity of them have been po...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research
Abstract Abnormal toll-like receptor (TLR) activation and uncontrolled resolution of inflammation are suspected to play a key role in the development of autoimmune diseases. Acquired myasthenia gravis (MG) is an invalidating neuromuscular disease leading to muscle weaknesses. MG is mainly mediated by anti-acetylcholine receptor (AChR) autoantibodies, and thymic hyperplasia characterized by ectopic germinal centers is a common feature in MG. An abnormal expression of certain TLRs is observed in the thymus of MG patients associated with the overexpression of interferon (IFN)-β, the orchestrator of thymic change...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Director chair, film slate and load horn. Here’s a proposal for you: If, by following the Wheat Belly lifestyle, a long list of conditions are reduced or reversed at no risk, almost no cost, reversing even chronic and potentially fatal conditions . . . does that mean that the notion of self-directed health might be on the horizon, i.e., putting control over health back in our own hands? I think it does. No, we will never implant our own defibrillators or take out our own gallbladders. But so many chronic health conditions afflicting modern humans recede that I believe that it is entirely reasonable to start talking a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle arthritis autoimmune diabetes eating disorder gluten grains Inflammation joint Weight Loss Source Type: blogs
Background There is no prognostic test to predict generalized myasthenia gravis (GMG) risk in patients with ocular disease. We aimed to create a predictive risk score. Method Multi-centre retrospective cohort study: OMG for minimum 3 months, untreated with immunosuppression for minimum 2 years or until GMG onset. Results 101 (57F) patients included. Median follow-up 8.4 y(2–42) from onset. 31 developed GMG at median 1.31 y (3.5 mo–20.2 y); 19 within 2 y. 3 significant predictors from univariable logistic regression analysis (p
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Neuromuscular disease, Ophthalmology ABN abstracts 2015 ABN Annual Meeting, 10 September 2015, Institute of Education, London Source Type: research
Lambert Eaton Myasthenic Syndrome (LEMS) is an autoimmune disorder affecting the neuromuscular junction caused by antibodies against voltage gated calcium channel antibodies. The neurophysiological hallmark of LEMS is incremental response to repetitive nerve stimulation, especially at high frequency stimulation. A 54-year-old gentleman presented to the Neurology clinic with a 9-month history of progressive walking difficulty. He had difficulty standing up from a sitting down position and the symptoms were worse towards the end of the day. He had a transient history of dry mouth when the symptoms started, but denied any pos...
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Neuromuscular disease, Ophthalmology, Musculoskeletal syndromes Thur 21, Parallel session 5: Therapeutics Source Type: research
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