FAK Expression, Not Kinase Activity, Is a Key Mediator of Thyroid Tumorigenesis and Protumorigenic Processes

This study demonstrates that FAK expression, but not kinase activity alone, predominantly mediates thyroid tumor growth and metastasis, indicating that targeting the scaffolding function(s) of FAK may be an important therapeutic strategy for advanced thyroid cancer, as well as other FAK-dependent tumors. Mol Cancer Res; 14(9); 869–82. ©2016 AACR.

Source: Molecular Cancer Research - September 12, 2016 Category: Cancer & Oncology Authors: Kessler, B. E., Sharma, V., Zhou, Q., Jing, X., Pike, L. A., Kerege, A. A., Sams, S. B., Schweppe, R. E. Tags: Signal Transduction Source Type: research