T-lymphoid progenitors - we know what they are, but know not what they may be

This study not only supports that the lymphoid fate of early T-cell progenitors is not yet fully stabilized but also shows that under oncogenic conditions, this multilineage plasticity potential of T-lymphoid progenitors can lead to transdifferentiation into myeloid leukemia. While gene expression profiles suggest that approximately 5% of all AML cases originate from T-lymphoid progenitors, novel treatment strategies targeting JAK2/STAT3 signaling might open new avenues for this AML cohort.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cancer, Development & Differentiation, Immunology News [amp ] Views Source Type: research