First time flu infection may affect lifetime immunity

Conclusion This modelling study shows how the strains of influenza A – "bird flu" – circulating when a person is born give them lifelong protection against new subtypes with the same H protein groups. The researchers call this immune imprinting. This may help to explain the high severity and mortality rate seen among certain groups. For example, the massive flu pandemic of 1918 was an H1N1 strain. This had a very high fatality rate among young adults, which the researchers consider may have been because when they were born (between 1880 and 1900), H3 was the dominant strain. Therefore they had no protection when encountering H1. However, elderly adults of the same generation did have protection when H3 peaked in 1968. These observations, however, aren't really too unexpected. It's already well known that the flu virus has many different strains; which is why people catch flu several times in their life, and why it's difficult to say the flu vaccine will definitely stop you catching flu (vaccines only cover the strain expected to be circulating that season). We also know that exposure to a specific virus gives us protection against the same if we encounter it again. So in that sense this isn't really "news" as such. Nevertheless, as the researchers say, their findings could help in planning for future flu outbreaks, in knowing which age groups may be most at risk. Though these are only modelling estimates so it's difficult to give certain answer...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

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ConclusionsTreatment with warfarin or aspirin both lead to similar outcomes after surgical bAVR. Combining aspirin with warfarin may lead to a small decrease in thromboembolism and mortality but is accompanied by increased bleeding. For TAVR patients, aspirin is equivalent to DAPT for reducing thromboembolism and mortality, with a possible decrease in bleeding.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
In conclusion, infants with Th1 and Th2 profile chemokines demonstrated a good response to vaccination, indicated by CXCL10 levels, but not infants predominantly Th2-skewed profile. These results highlight that children from mothers sensitized to S. mansoni may lead to ineffective immune response to PPD, while mothers sensitized to A. lumbricoides showed no such impairment.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
The US watchdog that is supposed to protect patients is in thrall to an industry profiting from addictionYears into America ’sopioid epidemic, as the death toll climbed into the hundreds of thousands, the US Food and Drug Administration (FDA) held a hearing to consider a drug company application to approve a new high-strength painkiller.The FDA assembles advisory committees of doctors and scientists to weigh the arguments for and against new drugs. In 2012, an opioid 10 times more powerful than regular painkillers, Zohydro ER, was on the agenda. By then, no one was in any doubt about the ravages of the worst drug epi...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Opioids Opioids crisis Pharmaceuticals industry Regulators NHS Health Drugs Society US news Science UK news Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
r Lal Influenza still remains one of the most challenging diseases, posing a significant threat to public health. Host lipid rafts play a critical role in influenza A virus (IAV) assembly and budding, however, their role in polyvalent IAV host binding and endocytosis had remained elusive until now. In the present study, we observed co-localization of IAV with a lipid raft marker ganglioside, GM1, on the host surface. Further, we isolated the lipid raft micro-domains from IAV infected cells and detected IAV protein in the raft fraction. Finally, raft disruption using Methyl-β-Cyclodextrin revealed significant r...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study was conducted to assess WTP, its explanatory variables, and the impact of financial compensation on WTP in Indonesia. A health facility-based cross-sectional study was conducted in eleven regencies in the Aceh and West Sumatra provinces of Indonesia. Participants were recruited via a convenience sampling method and were interviewed. The associations between explanatory variables and WTP were assessed using a two-step logistic regression analysis. A total of 1,102 parents were approached, and of these 956 (86.8%) completed the interview and were included in analysis. Of those, 144 (15.1%) were willing to particip...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ConclusionsHPV prevalence in the oral mucosa of the assessed FA patients was higher than reported in the general population. Additional studies with collection of sequential samples are needed to know the natural history of the presence of multiple HPV types in these individuals and its association with the development of tumors, to evaluate the implementation of preventive measures, such as vaccination, and to guide early treatment.This article is protected by copyright. All rights reserved.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Tags: Original Report Source Type: research
Publication date: December 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 6Author(s):
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsResults suggest that the nicotine patch incentives motivated women to call the Helpline, even pregnant women who needed a physician's approval consistent with current American College of Obstetricians and Gynecologists cautions about the appropriateness of the patch during pregnancy.Supplement informationThis article is part of a supplement entitled Advancing Smoking Cessation in California's Medicaid Population, which is sponsored by the California Department of Public Health.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
CONCLUSION: The aim of this review, other than providing a summarized update on the clinical knowledge on this special topic, is also to raise awareness for the need to conduct larger systematic studies in order to adequately evaluate the use of biologics in these special patient categories and therefore draw definite conclusions on their safety profile. PMID: 30428753 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
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