First time flu infection may affect lifetime immunity

Conclusion This modelling study shows how the strains of influenza A – "bird flu" – circulating when a person is born give them lifelong protection against new subtypes with the same H protein groups. The researchers call this immune imprinting. This may help to explain the high severity and mortality rate seen among certain groups. For example, the massive flu pandemic of 1918 was an H1N1 strain. This had a very high fatality rate among young adults, which the researchers consider may have been because when they were born (between 1880 and 1900), H3 was the dominant strain. Therefore they had no protection when encountering H1. However, elderly adults of the same generation did have protection when H3 peaked in 1968. These observations, however, aren't really too unexpected. It's already well known that the flu virus has many different strains; which is why people catch flu several times in their life, and why it's difficult to say the flu vaccine will definitely stop you catching flu (vaccines only cover the strain expected to be circulating that season). We also know that exposure to a specific virus gives us protection against the same if we encounter it again. So in that sense this isn't really "news" as such. Nevertheless, as the researchers say, their findings could help in planning for future flu outbreaks, in knowing which age groups may be most at risk. Though these are only modelling estimates so it's difficult to give certain answer...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

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Authors: PMID: 31104530 [PubMed - as supplied by publisher]
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
Publication date: July 2019Source: Preventive Medicine, Volume 124Author(s): Emma E. McGinty, Elizabeth M. Stone, Alene Kennedy-Hendricks, Colleen L. BarryAbstractPublic stigma toward people who use illicit drugs impedes advancement of public health solutions to the opioid epidemic and reduces willingness to seek addiction treatment. Experimental studies show that use of certain terms, such as “addict” and “substance abuser,” exacerbate stigma while alternative terms, such as “person with a substance use disorder,” are less stigmatizing. We examine the frequency with which stigmatizing t...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
The objective of the present study was to explore whether AT1-AA induced cardiomyocyte apoptosis was related to its inhibitory of miR-21 expression. In vivo studies, the pregnant rats were divided into two groups: Sham group, Model group. The pathology, cell apoptosis, and relative protein expressions were evaluated by hematoxylin and eosin staining, and Western blot assay. The expression of microRNA was detected by gene microarray. In the cell experiment, the neonatal rat cardiomyocytes were divided into four groups: NC group, AT1-AA group, and miR-21 group and AT1-AA+miR-21 group. The cell apoptosis and relative proteins...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: van Zuylen ML, Ten Hoope W, Bos E, Hermanides J, Stevens MF, Hollmann MW Abstract INTRODUCTION: Epidural analgesia is a popular approach to postoperative and labor pain. Neurotoxicity and drug-specific systemic side effects can occur after epidural administration. As an increasing number of epidural drugs are studied and clinically applied, drug efficacy and safety evaluation are crucial. Areas covered: In this narrative review, the authors provide a thorough overview on the safety of the most widely used epidural drugs, focusing on potential neurotoxicity, side effects, and complications in the adult, non...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
ConclusionsTreatment of cesarean scar pregnancy with a combination of systemic and local methotrexate was effective and safe. Although the treatment course tends to be longer than with other modalities, this protocol offers excellent success rates, with fertility preservation and few complications.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 30 April 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Camilla Pillay, Katherine ClarkAbstractTwenty-three percent of women with known chronic kidney disease (CKD) have been reported to demonstrate the first decline in kidney function between giving birth and six-weeks postpartum. As such, these women warrant close monitoring during the postpartum period irrespective of their pregnancy journey. Substantial haemodynamic variability during pregnancy and postpartum renders estimated glomerular filtration rate inaccurate, and poorly defined normal rang...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Nevada lawmakers are bucking a national trend of anti-abortion laws by voting to repeal requirements that physicians document a pregnant woman's marital status and tell her about the "emotional implications" of an abortion
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
This study compared neurodevelopmental outcomes of ante-partum and post-partum antiretroviral exposure in HIV-exposed and uninfected children with HIV-unexposed and uninfected children at ages 12, 24, 48, and 60 months.MethodsFor this study, a prospective cohort of HIV-exposed and uninfected children was identified from two research sites in the PROMISE-BF trial (at Blantyre, Malawi, and Kampala, Uganda), in which pregnant HIV-infected mothers were randomly assigned to triple antiretroviral prophylaxis (lopinavir–ritonavir plus either lamivudine and zidovudine or emtricitabine and tenofovir), versus zidovudine alone....
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Publication date: Available online 21 May 2019Source: Journal of Hospital InfectionAuthor(s): George Hills, Matthew Kennedy, Osama Ahmed, Julian W. Tang
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionThe incidence of motorized scooter related craniofacial trauma is rising, resulting in thousands of ED visits annually. Many patients are experiencing morbid traumatic injuries and may not be wearing appropriate protective equipment. This study highlights the importance of public awareness and policy to improve safety and primarily prevent craniofacial trauma.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
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