PRECISION: Celecoxib Similar to Ibuprofen, Naproxen for CV Risk PRECISION: Celecoxib Similar to Ibuprofen, Naproxen for CV Risk
Celecoxib hit its noninferiority CV mark against ibuprofen and naproxen in arthritis patients at increased CVD risk, but not all are convinced.Heartwire from Medscape
Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. PMID: 29670920 [PubMed - in process]
ConclusionBaricitinib 4 mg was efficacious compared to placebo in US and ROW subpopulations. Safety was similar between subgroups.FundingEli Lilly&Company and Incyte Corporation.Trial RegistrationClinicalTrials.gov identifiers, NCT01721057; NCT01710358.
AbstractWe compared the change in joint inflammation and the proportion of subjects achieving threshold levels of improvement using the existing methods employing ultrasonography on pre-determined joint sites versus novel methods. These novel methods select the most affected joints based on (i) ultrasonography —the Individualized-Ultrasound (IUS) method, or (ii) ultrasonography and clinical joint assessment—the individualized-Composite-Ultrasound (ICUS) method. Mean 3-month change in total inflammation score (ΔTIS) and 95% CI was computed for each method on 24 RA subjects initiated or escalated on tr eatm...
In this report, we presented a case of RA presenting with cervical spine involvement without peripheral arthritis to underline the importance of this kind of involvement in clinical practice. We also briefly reviewed other cases similar to ours in light of literature.
Authors: Ling S, Bluett J, Barton A PMID: 29667454 [PubMed - as supplied by publisher]
An experimental rheumatoid arthritis drug developed by Eli Lilly and Co and Incyte Corp poses serious risks of deadly blood clots at higher doses, U.S. Food and Drug Administration staff said on Thursday, the latest setback to a treatment regulators declined to approve last year.Reuters Health Information
Authors: McCarty MF, O'Keefe JH, DiNicolantonio JJ Abstract Although clinical trials with glucosamine in osteoarthritis have yielded mixed results, leading to doubts about its efficacy, the utility of glucosamine for preventing joint destruction and inflammation is well documented in rodent models of arthritis, including models of spontaneous osteoarthritis. The benefit of oral glucosamine in adjuvant arthritis is markedly dose dependent, likely reflecting a modulation of tissue levels of UDP-N-acetylglucosamine that in turn influences mucopolysaccharide synthesis and the extent of protein O-GlcNAcylation. Importan...
The biotech company hopes its research in placenta tissue will eventually help wounds heal and people with arthritis avoid joint replacements. The potential is huge — but so is the challenge of securing funding.
Condition: Rheumatoid Arthritis Interventions: Drug: Methotrexate; Drug: Adalimumab Sponsors: Keio University; Eisai Co., Ltd. Not yet recruiting
Restoration of vitamin D is one of the most powerful health strategies to have come along in years. Combine this with other Wheat Belly strategies and you have an exceptionally effective way to reverse the factors that allow numerous modern health conditions such as diabetes (type 1 and 2), hypertension, bone thinning, arthritis, depression, and autoimmune diseases. Vitamin D is such a crucial factor in health that you would therefore think that most doctors would be experts in vitamin D. Sadly, that is not the case. The majority of mainstream medical doctors are woefully ignorant, do not read the science nor try to unders...