Treatment-Related Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: A Comprehensive Review of Current Evidence and Future Needs

AbstractProgressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the central nervous system caused by the John Cunningham virus (JCV) that has been associated with therapeutic immunosuppression in patients with multiple sclerosis (MS). So far, more than 600 cases of PML have been reported in association with natalizumab administration. There have also been confirmed cases of PML in individuals who received fingolimod and dimethyl fumarate without previous natalizumab treatment. The new licensed disease-modifying therapies for MS carry the risk of immunosuppressant and so of JCV reactivation. Various factors have been identified with increased risk of developing PML, including a positive JCV serology, natalizumab administration for  >2  years, and prior use of immunosuppressive agents. Clinicians can employ such tools for patients’ risk stratification, but the incidence of PML among patients receiving natalizumab therapy has not changed. In this review we outline the current state of understanding of PML pathogenesis and patien ts’ risk stratification. The landscape of MS is dramatically changing and knowledge of the side effects of the licensed therapies is imperative to enable optimal decision making.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

Related Links:

Publication date: Available online 9 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Brenda Bertado-Cortés, Claudia Venzor-Mendoza, Daniel Rubio-Ordoñez, José Renán Pérez-Pérez, Lucy Andrea Novelo-Manzano, Lyda Viviana Villamil-Osorio, María de Jesús Jiménez-Ortega, María de la Luz Villalpando-Gueich, Nayeli Alejandra Sánchez-Rosales, Verónica García-Talavera
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
CONCLUSIONS: Paramagnetic rims might be a characteristic MRI finding for MS, and therefore they have potential as an imaging marker for differentially diagnosing MS from NMOSD using 3-T MRI. PMID: 33029961 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Publication date: Available online 8 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): T. Leist, S. Cook, G. Comi, X. Montalban, G. Giovannoni, A. Nolting, D. Damian, S. Syed, A. Galazka
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 8 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Carlos MARTIN SANCHEZ, Jose I CALVO ARENILLAS, Fausto J BARBERO IGLESIAS, Emilio FONSECA SANCHEZ, Jose M SANCHEZ SANTOS, Ana M MARTIN NOGUERAS
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 8 October 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Yuanyuan Wang, Xiaoyu Tian, Huacheng Zheng, Yinghui Guo, Yuexian Zuo, Mengdi Cong, Huifeng Zhang
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 8 October 2020Source: Neurología (English Edition)Author(s): V.M. Rivera, F. Gracia, A. Díaz
Source: Neurologia - Category: Neurology Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Alfredo Damasceno, Luciana Ramalho Pimentel-Silva, Benito Pereira Damasceno, Fernando Cendes
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Miceline Mésidor, Marie-Pierre Sylvestre, Ruth Ann Marrie, Marie-Claude Rousseau
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): H-P Hartung, T Berger, RA Bermel, B Brochet, WM Carroll, T Holmøy, R Karabudak, J Killestein, C Nos, F Patti, A Perrin Ross, L Vanopdenbosch, T Vollmer, R Buffels, M Garas, K Kadner, M Manfrini, Q Wang, MS Freedman
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: This large study did not support that a high intake of fibre and/or a low intake of meat had a high impact on the risk of late-onset CID. PMID: 33029091 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
More News: Drugs & Pharmacology | Gilenya | Multiple Sclerosis | Tysabri