Treat-to-Target the New Goal in Lupus

(MedPage Today) -- An international task force has taken the first steps toward formulating a "treat to target" approach for the treatment of systemic lupus erythematosus (SLE), focusing on remission, damage prevention, and quality of life.
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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Maira Giannelou, Dimitrios Tseronis, Eleni Antypa, Clio P. Mavragani
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusions With inclusion of LAC, the ELISA and CIA show comparable performance for the diagnosis of APS. However, correlations of APS-specific manifestations were dependent on method of detecting the aPL antibodies suggesting platforms may not be used interchangeable.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
A woman with cystic fibrosis and lung transplants suffered chronic pain for three years after she had a tattoo on her thighGetting a tattoo if you have a weakened immune system could put you at risk of complications, doctors have warned. The caution comes after a woman with cystic fibrosis and lung transplants developed thigh and knee pain after having body art inked on her leg.Doctors say those taking immunosuppressant drugs should take precautions if considering body art. These medicines are often given after an organ transplant or to treat autoimmune conditions such as Crohn ’s disease, lupus or rheumatoid arthrit...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Tattoos Medical research Immunology Biochemistry and molecular biology Health Cystic fibrosis Diabetes Source Type: news
Two UAB researchers have received Novel Research grants from the Lupus Research Alliance.   The grants, which total $100,000 for up to three years, were awarded to Andre Ballesteros-Tato and Frances Lund. The grants are aimed toward developing targeting treatments for lupus, a complex auto-immune disorder that has widespread and varied effects throughout the body. The professors are two of nine researchers nationwide who were awarded these grants to explore lupus from many different perspectives…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
AbstractAnti-U1-RNP positivity remains mandatory for the mixed connective tissue disease (MCTD) diagnosis, reason for which anti-U1-RNP occurrence in patients with lupus clinical features might determine diagnostic issues. Thus, the prevalence of 25 –30% for anti-RNP was reported in John Hopkins and LUMINA lupus cohorts and also 13% prevalence for the anti-U1-RNP in Euro-Lupus cohort. Presence of anti-U1-RNP antibodies in patients fulfilling SLE criteria (but not the MCTD ones) was associated with manifestations such as Raynaud phenomenon, mu sculoskeletal and lung impairment or nail fold capillaroscopy changes, some...
Source: Rheumatology International - Category: Rheumatology Source Type: research
The objective of this study was to evaluate the susceptibility of emerging fungi to fluconazole, itraconazole and amphotericin B by disk diffusion method. In 2015, 82 emerging fungi were evaluated in IPB-LACEN/RS and 13 (15.8%) were resistant: 10/52 were from superficial mycoses and 3/30 from systemic mycoses. The data from the study point to the need for permanent vigilance regarding the careful evaluation in the prescription and clinical and laboratory follow-up of patients affected by fungal infections.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
The objective of this study was to evaluate the susceptibility of emerging fungi to fluconazole, itraconazole and amphotericin B by disk diffusion method. In 2015, 82 emerging fungi were evaluated in IPB-LACEN/RS and 13 (15.8%) were resistant: 10/52 were from superficial mycoses and 3/30 from systemic mycoses. The data from the study point to the need for permanent vigilance regarding the careful evaluation in the prescription and clinical and laboratory follow-up of patients affected by fungal infections.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.8b00192
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Using social media to promote medication adherence, Published online: 18 June 2018; doi:10.1038/s41584-018-0037-1Poor medication adherence and depression interfere with the management of patients with systemic lupus erythematosus, especially adolescent and young adult patients. For patients for whom clinic visits and education programs fail to improve adherence, novel social media-based interventions are demonstrating the ability to increase patient agency, self-efficacy, and adherence.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
Authors: Le Bot A, Jégo P, Donal E, Flécher E, Revest M, Tattevin P Abstract Non-infective endocarditis, also referred to as non-bacterial thrombotic endocarditis, represent a wide range of rare pathologies, often severe. This review gathered the data available in the literature, to decipher the major information collected on the pathophysiology, the diagnosis and the treatment of these heterogeneous diseases, often misdiagnosed. Characteristics of non-infective endocarditis are similar to infective endocarditis in terms of valvular lesions (mostly left-sided, with regurgitations and vegetations), and...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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