Vitamin D and respiratory health in the Busselton healthy ageing study

Background:Studies report an association between respiratory disease such as asthma, COPD and low serum Vitamin D (VitD) levels.Aim:To assess serum VitD level as an independent risk factor for respiratory health outcomes in the Busselton Healthy Ageing Study.Methods:A cross-sectional questionnaire-based study of 3057 adults,born 1946-1964. Serum 25(OH)-VitD levels were measured by immunoassay on Abbott ARCHITECT platform (120 samples also assayed by LCMS) and were related to respiratory outcomes: asthma, bronchitis, hay fever/allergic rhinitis, pneumonia/pleurisy, OSA, wheeze, dyspnoea, cough/phlegm, chest tightness, reported COPD, FEV1%pred, FVC% pred and FEV1/FVC. Adjustments were made for age, sex, season of blood sample collection, use of vitamin supplements, ethnicity, and smoking(Model A), plus BMI and physical activity level(Model B), plus history of chronic diseases: diabetes, cardiovascular, cancer, chronic pain, depression(Model C).Results:45% male, mean age 56.7, BMI 28.23 ± 5.1, 10% smokers, 42% ex-smokers and 13% taking VitD supplements. VitD levels were
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 6.1 Epidemiology Source Type: research

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